Bengals vs Bills Prediction, Odds & Best Bets for AFC Divisional Round Playoff Game (Buffalo Prevails in Slugfest)

Updated: Sep 10, 5:00pm UTC

Bengals vs Bills Divisional Round Game Info

2022 NFL Playoffs — AFC Divisional Round Game
Cincinnati Bengals (13-4, 6-3 Away) vs. Buffalo Bills (14-3, 8-1 Home)
Date: Sunday, Jan. 22, 2023
Time: 3:00 p.m. ET
Venue: Highmark Stadium — Orchard Park, NY
Coverage: CBS

Two of the best offensive teams in the NFL will square off during the Divisional Round of the NFL Playoffs as the Cincinnati Bengals face the Buffalo Bills.

Both teams survived scares in the Wild Card Round despite being heavily favored against teams using their backup quarterbacks, coming back to win one-possession games. They'll need to be much sharper here if they want to advance to the AFC Championship Game.

Bengals vs Bills Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: CIN: (+176) | BUF: (-210)
Spread: CIN: +4 (-110) | BUF: -4 (-110)
Total: 50.5 — Over: (-106) | Under: (-114)
Odds to Win Super Bowl: CIN: +650 | BUF: +360

The Bills enter this contest as solid home favorites on the moneyline and spread on FanDuel Sportsbook's odds. This Sunday afternoon clash also features one of the highest totals on the Divisional Round slate at 50.5 points.

Bengals vs Bills Prediction & Pick

This game is a highly anticipated rematch of the Week 17 showdown between these two teams, which was cut short and ultimately canceled after Bills safety Damar Hamlin collapsed on the field. Thankfully, Hamlin is okay and will be cheering on his teammates as they try to move on to the next round.

Both teams are coming in incredibly hot after finishing the season on a tear. Buffalo has won eight straight games, while Cincinnati has won nine in a row. One of those winning streaks will come to an end here, however.

While both clubs are legit Super Bowl contenders, we think the Bills will prevail here. They hold the slight edge on both sides of the ball, ranking second in points scored and points allowed compared to the Bengals' rankings of sixth and seventh, respectively. Buffalo also has the advantage of playing at home, where the Bills are 8-1 this year including the playoffs.

Accordingly, expect Buffalo to come out on top in a close, high-scoring game between two powerhouses.

Final Score Prediction: Bills: 31 | Bengals: 28

Bengals vs Bills Betting Trends

- The Bengals are 12-4-1 against the spread this season, including 7-2 on the road.
- The Bills are 2-5 ATS in their last seven home games.
- The under is 4-0 in Cincinnati's last four playoff road games.
- The total has gone over in seven of the last 10 games between Cincy and Buffalo.

Bengals vs Bills Best Bet

As mentioned above, neither side has a clear-cut edge here. In such a close matchup, we're inclined to take the points with Cincinnati.

Joe Burrow is 4-1 in the playoffs so far, including 2-0 on the road. He clearly isn't scared of big moments and won't be intimidated by the Buffalo crowd after going 6-3 on the road this year.

This game will probably be decided by a field goal either way, so we like the Bengals to cover the +4 spread, as they could easily win outright as well.