St. John's vs Creighton College Basketball Prediction, Odds, Picks, Best Bets for Feb. 21

The St. John's Red Storm (21-5, 14-1 Big East) will host the Creighton Bluejays (14-13, 8-8 Big East) after winning five home games in a row.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

St. John's vs. Creighton Game Info and Odds

• Game day: Saturday, February 21, 2026
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: New York City, New York
• Arena: Madison Square Garden

St. John's vs. Creighton Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: St. John's win (90.8%)

If you plan to place a wager on St. John's-Creighton matchup (in which St. John's is a 13.5-point favorite and the total has been set at 155.5 points), keep reading for some betting trends and insights for Saturday's game.

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St. John's vs. Creighton: ATS Betting Stats and Trends

• St. John's has won 14 games against the spread this season, while failing to cover 12 times.
• Creighton has put together a 9-18-0 record against the spread this year.
• As a 13.5-point underdog or more in 2025-26, Creighton is 1-0 against the spread compared to the 4-4 ATS record St. John's puts up as a 13.5-point favorite.
• Against the spread, the Red Storm have played worse at home, covering six times in 14 home games, and six times in eight road games.
• Against the spread, the Bluejays have had better results away (4-6-0) than at home (4-10-0).
• St. John's has covered the spread nine times in 15 conference games.
• Creighton's Big East record against the spread is 5-11-0.

St. John's vs. Creighton: Moneyline Betting Stats

• St. John's has been chosen as the moneyline favorite in 22 games this year and has walked away with the win 19 times (86.4%) in those games.
• The Red Storm have not lost in seven games this year when favored by -1250 or better on the moneyline.
• Creighton has been the underdog on the moneyline 12 total times this season. Creighton has gone 3-9 in those games.
• The Bluejays have played as a moneyline underdog of +740 or longer in just one game this season, which they won.
• Oddsmakers have implied with the moneyline set for this matchup that St. John's has a 92.6% chance of pulling out a win.

St. John's vs. Creighton Head-to-Head Comparison

• On offense, St. John's was the 65th-ranked squad in the country (78.5 points per game) last year. On defense, it was 27th (65.8 points allowed per game).
• On the glass, St. John's was eighth-best in the nation in rebounds (36.9 per game) last year. It was 182nd in rebounds allowed (31.2 per game).
• Last season St. John's was ranked 53rd in the nation in assists with 15.7 per game.
• In terms of turnovers, St. John's was 98th in college basketball in committing them (10.3 per game) last year. It was 17th-best in forcing them (14.2 per game).
• Offensively, Creighton put up 75.5 points per game (131st-ranked in college basketball) last season. It ceded 70 points per contest at the other end (110th-ranked).
• Last season Creighton averaged 34.4 boards per game (53rd-ranked in college basketball) and allowed 31.1 rebounds per contest (172nd-ranked).
• Creighton was one of the best teams in college basketball in terms of assists, as it averaged 17.1 per game (13th-best in college basketball).
• Creighton, who was 215th in college basketball with 11.4 turnovers per game, forced 7.4 turnovers per contest, which was -4-worst in the country.

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