Red Sox vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 5

Odds updated as of 4:13 a.m.

The MLB's Sunday schedule includes the Boston Red Sox facing the San Diego Padres.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Padres Game Info

• Boston Red Sox (2-6) vs. San Diego Padres (3-5)
• Date: Sunday, April 5, 2026
• Time: 1:35 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and Padres.TV

Red Sox vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-148) | SD: (+126)
• Spread: BOS: -1.5 (+130) | SD: +1.5 (-156)
• Total: 9 -- Over: (-110) | Under: (-110)

Red Sox vs Padres Probable Starting Pitchers

Probable Pitchers: Ranger Suarez (Red Sox) - 0-1, 8.31 ERA vs Walker Buehler (Padres) - 0-1, 6.75 ERA

The Red Sox will call on Ranger Suarez (0-1) versus the Padres and Walker Buehler (0-1). Suarez and his team failed to cover the spread in his only opportunity this season as a starter. Suarez's team lost his only start as a favorite this season. Buehler has started just one game with a set spread, which the Padres covered. The Padres have not been a moneyline underdog when Buehler starts this season.

Red Sox vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (57%)

Red Sox vs Padres Moneyline

• Boston is the favorite, -148 on the moneyline, while San Diego is a +126 underdog on the road.

Red Sox vs Padres Spread

• The Padres are at +1.5 on the runline against the Red Sox. The Padres are -156 to cover the spread, and the Red Sox are +130.

Red Sox vs Padres Over/Under

• An over/under of 9 has been set for Red Sox-Padres on April 5, with the over being -110 and the under -110.

Bet on Boston Red Sox vs. San Diego Padres on FanDuel today!

Red Sox vs Padres Betting Trends

• The Red Sox have won in two of the seven contests they have been named as odds-on favorites in this year.
• Boston has been listed as a favorite of -148 or more on two occasions this season and split those games.
• The Red Sox's games have gone over the total in four of their eight opportunities.
• The Red Sox are 2-6-0 against the spread in their eight games that had a posted line this season.
• The Padres have put together a 1-3 record in games they were listed as the moneyline underdog (winning 25% of those games).
• San Diego has not played a game this season with moneyline odds of +126 or longer.
• In the eight games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total two times (2-5-1).
• The Padres are 4-4-0 against the spread this season.

Red Sox Player Leaders

• Wilyer Abreu has 12 hits and an OBP of .406 to go with a slugging percentage of .774. All three of those stats lead Boston hitters this season. He has a .387 batting average, as well.
• Among all qualified hitters, he ranks 10th in batting average, his on-base percentage ranks 34th, and he is sixth in slugging.
• Abreu has picked up at least one hit in three games in a row. In his last five games he is batting .333 with a double, a home run, a walk and two RBIs.
• Marcelo Mayer has three doubles, a home run and two walks. He's batting .250 and slugging .550 with an on-base percentage of .304.
• Jarren Duran has five hits this season and has a slash line of .200/.333/.240.
• Duran takes a three-game hitting streak into this matchup. During his last five outings he is hitting .176 with a double, three walks and an RBI.
• Willson Contreras has one home run, two RBI and a batting average of .185 this season.
• Contreras brings a four-game hitting streak into this matchup. During his last five outings he is batting .222 with a home run, two walks and two RBIs.

Padres Player Leaders

• Ramon Laureano has eight hits with a .577 slugging percentage, both team-best figures for the Padres. He's batting .308 and with an on-base percentage of .357.
• Including all qualified hitters in the majors, his batting average places him 40th, his on-base percentage is 74th, and he is 27th in slugging.
• Manny Machado has a .438 on-base percentage to lead his team. He has a batting average of .217 while slugging .304.
• He is currently 122nd in batting average, 19th in on-base percentage and 136th in slugging percentage among all qualified hitters.
• Jackson Merrill is batting .185 with a double, a home run and two walks.
• Fernando Tatis Jr. is batting .200 with two doubles and four walks.

Red Sox vs Padres Head to Head

• 4/4/2026: 3-2 SD (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/3/2026: 5-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/10/2025: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/9/2025: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/8/2025: 10-2 BOS (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/30/2024: 4-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 10, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/29/2024: 11-1 SD (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/28/2024: 9-2 SD (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/21/2023: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/20/2023: 4-2 BOS (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)

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