Padres vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for April 15

Odds updated as of 6:13 a.m.

The Wednesday slate in MLB includes a matchup between the San Diego Padres and the Seattle Mariners.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Mariners Game Info

• San Diego Padres (11-6) vs. Seattle Mariners (8-10)
• Date: Wednesday, April 15, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Mariners.TV

Padres vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-112) | SEA: (-104)
• Spread: SD: +1.5 (-184) | SEA: -1.5 (+152)
• Total: 8 -- Over: (-115) | Under: (-105)

Padres vs Mariners Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 1-0, 1.02 ERA vs Emerson Hancock (Mariners) - 2-1, 2.04 ERA

The Padres will give the ball to Randy Vasquez (1-0, 1.02 ERA), who is eyeing win No. 2 on the season, and the Mariners will turn to Emerson Hancock (2-1, 2.04 ERA). Vasquez and his team have covered in each of the three games he's started with a spread this season. Vasquez's team won his only start as a favorite this season. When Hancock starts, the Mariners have gone 2-1-0 against the spread. The Mariners have not been the underdog on the moneyline when Hancock starts this season.

Padres vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (50.6%)

Padres vs Mariners Moneyline

• The Padres vs Mariners moneyline has San Diego as a -112 favorite, while Seattle is a -104 underdog on the road.

Padres vs Mariners Spread

• The Mariners are 1.5-run favorites against the spread for this matchup with the Padres. The Mariners are +152 to cover, while the Padres are -184 to cover as a 1.5-run underdog on the runline.

Padres vs Mariners Over/Under

• Padres versus Mariners on April 15 has an over/under of 8 runs, with the odds on the over -115 and the under set at -105.

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Padres vs Mariners Betting Trends

• The Padres have been victorious in six of the eight contests they have been chosen as favorites in this season.
• San Diego has a record of 6-2 in contests when sportsbooks favor them by -112 or more on the moneyline.
• The Padres and their opponents have hit the over in eight of their 17 games with a total set by oddsmakers this season.
• The Padres are 12-5-0 against the spread in their 17 games that had a posted line this season.
• The Mariners have a 1-2 record in games they were listed as the moneyline underdog (winning 33.3% of those games).
• Seattle has played as a moneyline underdog of -104 or longer in just two games this season, which it split 1-1.
• In the 18 games oddsmakers have set an over/under for the Mariners, they have combined with opponents to go over the total eight times (8-10-0).
• The Mariners have gone 7-11-0 ATS this season.

Padres Player Leaders

• Jackson Merrill has four doubles, three home runs and six walks while hitting .250. He has an on-base percentage of .314 and a slugging percentage of .453.
• Among the qualified hitters in the majors, his batting average ranks 82nd, his on-base percentage ranks 115th, and he is 66th in slugging.
• Merrill hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .368 with two doubles, a home run, three walks and four RBIs.
• Ramon Laureano leads San Diego with 17 hits and a team-best slugging percentage of .567. He's batting .283 with an on-base percentage of .348.
• He ranks 55th in batting average, 70th in on-base percentage and 16th in slugging in MLB.
• Laureano enters this matchup looking to extend his four-game hit streak. During his last five outings he is batting .400 with a double, a triple, two home runs, three walks and five RBIs.
• Xander Bogaerts has hit two homers with a team-high .397 SLG this season.
• Bogaerts enters this game with two games in a row with at least one hit. During his last five outings he is batting .350 with a home run, three walks and seven RBIs.
• Manny Machado leads San Diego with an OBP of .368 this season while batting .196 with 15 walks and nine runs scored.

Mariners Player Leaders

• Randy Arozarena has put up a slugging percentage of .381, a team-high for the Mariners. He's batting .286 with an on-base percentage of .408.
• Including all the qualifying hitters in the majors, his batting average places him 51st, his on-base percentage is 18th, and he is 97th in slugging.
• Brendan Donovan's .417 OBP paces his team. He has a batting average of .292 while slugging .542.
• Including all qualifying players, he is 42nd in batting average, 13th in on-base percentage and 27th in slugging percentage.
• Cole Young has two doubles, a triple, two home runs and seven walks while hitting .230.
• Luke Raley leads his team with 16 hits.

Padres vs Mariners Head to Head

• 4/14/2026: 4-1 SD (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/27/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/26/2025: 7-6 SD (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/25/2025: 9-6 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/18/2025: 6-1 SEA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2025: 4-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/16/2025: 5-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/11/2024: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/10/2024: 7-3 SD (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/10/2024: 2-0 SEA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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