North Carolina vs Syracuse College Basketball Prediction, Odds, Picks, Best Bets for Feb. 21

The Syracuse Orange (15-12, 6-8 ACC) will attempt to extend a three-game home win streak when they square off against the North Carolina Tar Heels (20-6, 8-5 ACC) on February 21, 2026 at JMA Wireless Dome.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Syracuse vs. North Carolina Game Info and Odds

• Game day: Saturday, February 21, 2026
• Game time: 1 p.m. ET
• TV channel: ABC
• Location: Syracuse, New York
• Arena: JMA Wireless Dome

Syracuse vs. North Carolina Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: North Carolina win (62.7%)

Before making an informed wager on Syracuse-North Carolina contest (in which Syracuse is a 1.5-point favorite and the total is set at 153.5 points), here are some betting insights and trends for Saturday's game.

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Syracuse vs. North Carolina: ATS Betting Stats and Trends

• Syracuse has covered 14 times in 27 matchups with a spread this season.
• North Carolina has compiled a 13-13-0 record against the spread this season.
• When the spread is set as 1.5 or more this season, Syracuse (8-7) covers a lower percentage of those games when it is the favorite (53.3%) than North Carolina (3-2) does as the underdog (60%).
• At home, the Orange have a worse record against the spread (8-8-0) compared to their ATS record in away games (4-3-0).
• This year, the Tar Heels are 9-6-0 at home against the spread (.600 winning percentage). On the road, they are 3-5-0 ATS (.375).
• Syracuse has eight wins against the spread in 14 conference games this season.
• North Carolina has five wins against the spread in 13 ACC games this year.

Syracuse vs. North Carolina: Moneyline Betting Stats

• Syracuse has been victorious in 12, or 80%, of the 15 contests it has been chosen as moneyline favorites in this season.
• This season, the Orange have come away with a win 12 times in 15 chances when named as a favorite of at least -120 or shorter on the moneyline.
• North Carolina is 3-3 in games it was listed as the moneyline underdog (winning 50% of those games).
• The Tar Heels have a 3-1 record (winning 75% of their games) when playing as a moneyline underdog of +100 or longer.
• The moneyline set for this matchup implies Syracuse has a 54.5% chance of walking away with the win.

Syracuse vs. North Carolina Head-to-Head Comparison

• Syracuse was 147th in the country in points scored (74.7 per game) and 322nd in points conceded (77.8) last year.
• Last year, Syracuse was 75th in the nation in rebounds (33.6 per game) and 172nd in rebounds conceded (31.1).
• Syracuse was 174th in the nation in assists (13.6 per game) last year.
• Syracuse was 259th in the nation in turnovers per game (12) and 25th-worst in turnovers forced (9.5) last year.
• Offensively, North Carolina averaged 80.7 points per game (29th-ranked in college basketball) last season. It gave up 74.7 points per contest at the other end of the court (261st-ranked).
• North Carolina grabbed 33.2 boards per game (105th-ranked in college basketball). It gave up 31.2 rebounds per contest (182nd-ranked).
• North Carolina averaged 14.7 dimes per game, which ranked them 93rd in the nation.
• Last year North Carolina averaged 10.5 turnovers per game (120th-ranked in college basketball) and forced 10.2 turnovers per contest (288th-ranked).

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