NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 15

The Detroit Lions and the Los Angeles Rams take the field in one of many compelling matchups on the NFL schedule in Week 15.

If you're looking for additional betting info for Week 15 in the NFL, we've got you covered with betting odds for each of the important matchups.

Buccaneers vs. Falcons

Star running back Bijan Robinson and the Atlanta Falcons (4-9) play the Tampa Bay Buccaneers (7-6) on Thursday at 8:15 p.m. ET, at Raymond James Stadium.

• Game Preview: Atlanta Falcons at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (61.15% win probability)
• Spread: Tampa Bay (-4.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Tampa Bay vs. Atlanta with FanDuel Sportsbook.

Patriots vs. Bills

James Cook, who ranks second-best in the NFL in rushing yards, will try to lead the way for the Buffalo Bills (9-4) on Dec. 14 at 1 p.m. ET, when they visit the New England Patriots (11-2) and their third-best run D (89.5 rushing yards allowed per game).

• Game Preview: Buffalo Bills at New England Patriots
• Projected Favorite: Patriots (52.27% win probability)
• Spread: Buffalo (-1.5)
• Total: 49.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. Buffalo with FanDuel Sportsbook.

Eagles vs. Raiders

Brock Bowers and the Las Vegas Raiders (2-11) face the Philadelphia Eagles (8-5) on Sunday at 1 p.m. ET at Lincoln Financial Field.

• Game Preview: Las Vegas Raiders at Philadelphia Eagles
• Projected Favorite: Eagles (81.79% win probability)
• Spread: Philadelphia (-11.5)
• Total: 38.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Las Vegas with FanDuel Sportsbook.

Jaguars vs. Jets

The Jacksonville Jaguars (9-4) will host the New York Jets (3-10) on Sunday at 1 p.m. ET.

• Game Preview: New York Jets at Jacksonville Jaguars
• Projected Favorite: Jaguars (82.25% win probability)
• Spread: Jacksonville (-12.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. New York with FanDuel Sportsbook.

Chiefs vs. Chargers

Travis Kelce will lead the Kansas City Chiefs (6-7) into their matchup versus the Los Angeles Chargers (9-4) at GEHA Field at Arrowhead Stadium on Sunday at 1 p.m. ET.

• Game Preview: Los Angeles Chargers at Kansas City Chiefs
• Projected Favorite: Chiefs (68.01% win probability)
• Spread: Kansas City (-4.5)
• Total: 42.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Kansas City vs. Los Angeles with FanDuel Sportsbook.

Bears vs. Browns

The Chicago Bears (9-4) and the Cleveland Browns (3-10), who both lost their last tilt, will play at 1 p.m. ET on Sunday, Dec. 14. In their previous games, the Bears lost 28-21 to the Packers, and the Browns were defeated by the Titans 31-29.

• Game Preview: Cleveland Browns at Chicago Bears
• Projected Favorite: Bears (78.83% win probability)
• Spread: Chicago (-7.5)
• Total: 39.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. Cleveland with FanDuel Sportsbook.

Texans vs. Cardinals

Trey McBride and the Arizona Cardinals (3-10) will get a challenge when they go toe to toe with the Houston Texans (8-5), who sport the league's third-best pass defense, on Sunday, Dec. 14 at 1 p.m. ET. McBride ranks sixth-best in the league in receiving yards.

• Game Preview: Arizona Cardinals at Houston Texans
• Projected Favorite: Texans (78.33% win probability)
• Spread: Houston (-9.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Houston vs. Arizona with FanDuel Sportsbook.

Giants vs. Commanders

The New York Giants (2-11) and the Washington Commanders (3-10), who both lost their last game, will play at 1 p.m. ET on Sunday, Dec. 14. In their previous games, the Giants lost 33-15 to the Patriots, and the Commanders were taken down by the Vikings 31-0.

• Game Preview: Washington Commanders at New York Giants
• Projected Favorite: Giants (61.97% win probability)
• Spread: New York (-2.5)
• Total: 46.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Washington with FanDuel Sportsbook.

Bengals vs. Ravens

Against the Cincinnati Bengals (4-9), who have the worst run defense this season, Derrick Henry and the Baltimore Ravens (6-7) should have success running the ball when the two teams meet on Sunday, Dec. 14 at 1 p.m. ET. Henry has been one of the NFL's top rushers this season, ranking sixth-best in the league in rushing yards.

• Game Preview: Baltimore Ravens at Cincinnati Bengals
• Projected Favorite: Ravens (64.24% win probability)
• Spread: Baltimore (-2.5)
• Total: 51.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. Baltimore with FanDuel Sportsbook.

Seahawks vs. Colts

On Sunday at 4:25 p.m. ET, a pair of the top offensive performers in football will be on show when wide receiver Jaxon Smith-Njigba and the Seattle Seahawks (10-3) host running back Jonathan Taylor and the Indianapolis Colts (8-5).

• Game Preview: Indianapolis Colts at Seattle Seahawks
• Projected Favorite: Seahawks (72.79% win probability)
• Spread: Seattle (-13.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Seattle vs. Indianapolis with FanDuel Sportsbook.

Rams vs. Lions

Two of the league's most exciting offenses will match up on Sunday, Dec. 14 at 4:25 p.m. ET, when the Los Angeles Rams (10-3) and their fourth-ranked offense (29.2 points per game) challenge the Detroit Lions' (8-5) No. 1 scoring offense (30.3 points per game).

• Game Preview: Detroit Lions at Los Angeles Rams
• Projected Favorite: Rams (67.63% win probability)
• Spread: Los Angeles (-5.5)
• Total: 54.5 -- Over: (-120) | Under: (-102)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Detroit with FanDuel Sportsbook.

Saints vs. Panthers

On Sunday at 4:25 p.m. ET, the Carolina Panthers (7-6) will visit the New Orleans Saints (3-10).

• Game Preview: Carolina Panthers at New Orleans Saints
• Projected Favorite: Saints (53.81% win probability)
• Spread: Carolina (-2.5)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Carolina with FanDuel Sportsbook.

Broncos vs. Packers

On Sunday at 4:25 p.m. ET, a pair of the top offensive players in football will be on display when running back Josh Jacobs and the Green Bay Packers (9-3-1) visit quarterback Bo Nix and the Denver Broncos (11-2).

• Game Preview: Green Bay Packers at Denver Broncos
• Projected Favorite: Broncos (51.30% win probability)
• Spread: Green Bay (-2.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Denver vs. Green Bay with FanDuel Sportsbook.

49ers vs. Titans

Star running back Christian McCaffrey and the San Francisco 49ers (9-4) play the Tennessee Titans (2-11) on Sunday at 4:25 p.m. ET at Levi's Stadium.

• Game Preview: Tennessee Titans at San Francisco 49ers
• Projected Favorite: 49ers (89.76% win probability)
• Spread: San Francisco (-12.5)
• Total: 44.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Tennessee with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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