NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 15

The NFL slate in Week 15 is not one to miss. The outings include the Detroit Lions taking on the Los Angeles Rams at SoFi Stadium.

Read through our betting preview for the NFL's Week 15.

Buccaneers vs. Falcons

When the Tampa Bay Buccaneers (7-6) and the Atlanta Falcons (4-9) go head to head on Thursday, Dec. 11 at 8:15 p.m. ET, they will both be looking to rebound after losing their last game. The Buccaneers lost 24-20 to the Saints, and the Falcons are coming off a 37-9 loss to the Seahawks.

• Game Preview: Atlanta Falcons at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (62.52% win probability)
• Spread: Tampa Bay (-5.5)
• Total: 43.5 -- Over: (-105) | Under: (-115)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Tampa Bay vs. Atlanta with FanDuel Sportsbook.

Chiefs vs. Chargers

Patrick Mahomes and the Kansas City Chiefs (6-7) will get a tough test when they square off against the Los Angeles Chargers (9-4), who own the NFL's fifth-best pass D, on Sunday, Dec. 14 at 1 p.m. ET. Mahomes ranks third-best in the league in passing yards.

• Game Preview: Los Angeles Chargers at Kansas City Chiefs
• Projected Favorite: Chiefs (69.76% win probability)
• Spread: Kansas City (-5.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Kansas City vs. Los Angeles with FanDuel Sportsbook.

Eagles vs. Raiders

The Philadelphia Eagles (8-5) are set to match up with the Las Vegas Raiders (2-11) at Lincoln Financial Field on Sunday, Dec. 14 at 1 p.m. ET. Both squads lost their previous game, as the Eagles were taken down by the Chargers 22-19, and the Raiders lost 24-17 to the Broncos.

• Game Preview: Las Vegas Raiders at Philadelphia Eagles
• Projected Favorite: Eagles (81.79% win probability)
• Spread: Philadelphia (-11.5)
• Total: 37.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Las Vegas with FanDuel Sportsbook.

Patriots vs. Bills

Josh Allen and the Buffalo Bills (9-4) will visit Drake Maye and the New England Patriots (11-2) on Sunday at 1 p.m. ET, in a matchup between two excellent quarterbacks.

• Game Preview: Buffalo Bills at New England Patriots
• Projected Favorite: Patriots (51.50% win probability)
• Spread: Buffalo (-2.5)
• Total: 49.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. Buffalo with FanDuel Sportsbook.

Bears vs. Browns

At Soldier Field on Sunday, the Chicago Bears (9-4) play the Cleveland Browns (3-10).

• Game Preview: Cleveland Browns at Chicago Bears
• Projected Favorite: Bears (78.83% win probability)
• Spread: Chicago (-7.5)
• Total: 38.5 -- Over: (-106) | Under: (-114)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. Cleveland with FanDuel Sportsbook.

Texans vs. Cardinals

At NRG Stadium on Sunday, Nico Collins and the Houston Texans (8-5) face Trey McBride and the Arizona Cardinals (3-10) in a matchup featuring a pair of excellent pass-catchers, beginning at 1 p.m. ET.

• Game Preview: Arizona Cardinals at Houston Texans
• Projected Favorite: Texans (78.26% win probability)
• Spread: Houston (-10.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Houston vs. Arizona with FanDuel Sportsbook.

Giants vs. Commanders

The New York Giants (2-11) are in action on Sunday at 1 p.m. ET against the Washington Commanders (3-10) at MetLife Stadium.

• Game Preview: Washington Commanders at New York Giants
• Projected Favorite: Giants (61.97% win probability)
• Spread: New York (-2.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Washington with FanDuel Sportsbook.

Bengals vs. Ravens

Ja'Marr Chase and the Cincinnati Bengals (4-9) meet the Baltimore Ravens (6-7) on Sunday at 1 p.m. ET at Paycor Stadium.

• Game Preview: Baltimore Ravens at Cincinnati Bengals
• Projected Favorite: Ravens (65.09% win probability)
• Spread: Baltimore (-3)
• Total: 51.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. Baltimore with FanDuel Sportsbook.

Jaguars vs. Jets

At 1 p.m. ET on Sunday, the Jacksonville Jaguars (9-4) are at home against the New York Jets (3-10).

• Game Preview: New York Jets at Jacksonville Jaguars
• Projected Favorite: Jaguars (81.90% win probability)
• Spread: Jacksonville (-13.5)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. New York with FanDuel Sportsbook.

Seahawks vs. Colts

Jaxon Smith-Njigba and the Seattle Seahawks (10-3) will host Jonathan Taylor and the Indianapolis Colts (8-5) on Sunday at 4:25 p.m. ET, in a battle featuring a pair of the biggest stars in football on offense.

• Game Preview: Indianapolis Colts at Seattle Seahawks
• Projected Favorite: Seahawks (72.79% win probability)
• Spread: Seattle (-13.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Seattle vs. Indianapolis with FanDuel Sportsbook.

Saints vs. Panthers

The Carolina Panthers (7-6) play on Sunday at 4:25 p.m. ET against the New Orleans Saints (3-10) at Caesars Superdome.

• Game Preview: Carolina Panthers at New Orleans Saints
• Projected Favorite: Saints (53.81% win probability)
• Spread: Carolina (-2.5)
• Total: 40.5 -- Over: (-114) | Under: (-106)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Carolina with FanDuel Sportsbook.

Rams vs. Lions

The league's No. 1 scoring offense, the Detroit Lions (8-5), visit the Los Angeles Rams (10-3) and their fourth-ranked scoring offense on Sunday, Dec. 14 at 4:25 p.m. ET. The Lions score 30.3 points per game, while the Rams average 29.2 per game.

• Game Preview: Detroit Lions at Los Angeles Rams
• Projected Favorite: Rams (67.63% win probability)
• Spread: Los Angeles (-5.5)
• Total: 54.5 -- Over: (-120) | Under: (-102)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Detroit with FanDuel Sportsbook.

Broncos vs. Packers

Two of the best offensive performers in football will be on display when running back Josh Jacobs and the Green Bay Packers (9-3-1) visit quarterback Bo Nix and the Denver Broncos (11-2) on Sunday, December 14, 2025.

• Game Preview: Green Bay Packers at Denver Broncos
• Projected Favorite: Broncos (53.50% win probability)
• Spread: Green Bay (-1.5)
• Total: 42.5 -- Over: (-118) | Under: (-104)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Denver vs. Green Bay with FanDuel Sportsbook.

49ers vs. Titans

Christian McCaffrey and the San Francisco 49ers (9-4) play the Tennessee Titans (2-11) on Sunday at 4:25 p.m. ET, at Levi's Stadium.

• Game Preview: Tennessee Titans at San Francisco 49ers
• Projected Favorite: 49ers (89.76% win probability)
• Spread: San Francisco (-12.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Tennessee with FanDuel Sportsbook.

Cowboys vs. Vikings

Star running back Javonte Williams and the Dallas Cowboys (6-6-1) face the Minnesota Vikings (5-8) on Sunday at 8:20 p.m. ET at AT&T Stadium.

• Game Preview: Minnesota Vikings at Dallas Cowboys
• Projected Favorite: Cowboys (67.15% win probability)
• Spread: Dallas (-4.5)
• Total: 47.5 -- Over: (-114) | Under: (-106)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Dallas vs. Minnesota with FanDuel Sportsbook.

Steelers vs. Dolphins

De'Von Achane will lead the Miami Dolphins (6-7) into their matchup against the Pittsburgh Steelers (7-6) at Acrisure Stadium, on Monday at 8:15 p.m. ET.

• Game Preview: Miami Dolphins at Pittsburgh Steelers
• Projected Favorite: Dolphins (52.88% win probability)
• Spread: Pittsburgh (-3)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: ESPN

Bet on Pittsburgh vs. Miami with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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