NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 12

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NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 12

The NFL schedule in Week 12 is sure to please. The outings include the Detroit Lions playing the Indianapolis Colts at Lucas Oil Stadium.

Here's everything you need to know in terms of the betting odds for Week 12 in the NFL.

Browns vs. Steelers

When the Cleveland Browns (2-8) and the Pittsburgh Steelers (8-2) match up on Thursday, Nov. 21 at 8:15 p.m. ET, the Browns' 31st-ranked scoring offense will have some tough sledding ahead, as the Steelers have the second-ranked defense in the NFL.

Matchup: Pittsburgh Steelers at Cleveland Browns
Projected Favorite: Steelers (71.57% win probability)
Spread: Pittsburgh (-3.5)
Total: 36.5 -- Over: (-115) | Under: (-105)
Time: 8:15 p.m. ET
Channel: Amazon Prime Video

Bet on Cleveland vs. Pittsburgh with FanDuel Sportsbook.

Colts vs. Lions

Against the Indianapolis Colts (5-6), who sport the 28th-ranked run defense this season, Jahmyr Gibbs and the Detroit Lions (9-1) shouldn't have any trouble running the ball when the two teams come together on Sunday, Nov. 24 at 1 p.m. ET. Gibbs has been one of the NFL's top runners this year, ranking fifth-best in the league in rushing yards.

Matchup: Detroit Lions at Indianapolis Colts
Projected Favorite: Lions (65.39% win probability)
Spread: Detroit (-7.5)
Total: 50.5 -- Over: (-105) | Under: (-115)
Time: 1 p.m. ET
Channel: FOX

Bet on Indianapolis vs. Detroit with FanDuel Sportsbook.

Texans vs. Titans

The 1 p.m. ET tilt on Nov. 24 between the Houston Texans (7-4) and the Tennessee Titans (2-8) should be an exciting matchup, as C.J. Stroud has been one of the league's top passers this season, and the Titans have a top-five pass defense, ranking first in the NFL at 164.6 passing yards surrendered per contest.

Matchup: Tennessee Titans at Houston Texans
Projected Favorite: Texans (76.58% win probability)
Spread: Houston (-7.5)
Total: 40.5 -- Over: (-115) | Under: (-105)
Time: 1 p.m. ET
Channel: CBS

Bet on Houston vs. Tennessee with FanDuel Sportsbook.

Panthers vs. Chiefs

Chuba Hubbard, who ranks fourth-best in the NFL in rushing yards, will try to lead the way for the Carolina Panthers (3-7) on Nov. 24 at 1 p.m. ET, when they host the Kansas City Chiefs (9-1) and their third-best run defense (85.3 rushing yards allowed per game).

Matchup: Kansas City Chiefs at Carolina Panthers
Projected Favorite: Chiefs (71.15% win probability)
Spread: Kansas City (-10.5)
Total: 43.5 -- Over: (-102) | Under: (-120)
Time: 1 p.m. ET
Channel: CBS

Bet on Carolina vs. Kansas City with FanDuel Sportsbook.

Dolphins vs. Patriots

When the Miami Dolphins (4-6) and the New England Patriots (3-8) match up on Sunday, Nov. 24 at 1 p.m. ET, the Dolphins will be aiming to follow up their recent victory over the Raiders with another win, and the Patriots will be trying to rebound from a loss to the Rams.

Matchup: New England Patriots at Miami Dolphins
Projected Favorite: Dolphins (70.50% win probability)
Spread: Miami (-7)
Total: 46.5 -- Over: (-105) | Under: (-115)
Time: 1 p.m. ET
Channel: CBS

Bet on Miami vs. New England with FanDuel Sportsbook.

Bears vs. Vikings

The Minnesota Vikings (8-2), who defeated the Titans in their last game, visit the Chicago Bears (4-6) at Soldier Field on Nov. 24 at 1 p.m. ET. The Bears were taken down by the Packers in their last game.

Matchup: Minnesota Vikings at Chicago Bears
Projected Favorite: Vikings (64.80% win probability)
Spread: Minnesota (-3.5)
Total: 39.5 -- Over: (-105) | Under: (-115)
Time: 1 p.m. ET
Channel: FOX

Bet on Chicago vs. Minnesota with FanDuel Sportsbook.

Giants vs. Buccaneers

The Tampa Bay Buccaneers (4-6), who rank fifth in the league at 27.9 points per game, look to be in a very good spot on Sunday, Nov. 24 at 1 p.m. ET, as they get to square off against the New York Giants (2-8), who have the league's worst scoring offense (15.6 points per game).

Matchup: Tampa Bay Buccaneers at New York Giants
Projected Favorite: Buccaneers (66.31% win probability)
Spread: Tampa Bay (-5.5)
Total: 41.5 -- Over: (-105) | Under: (-115)
Time: 1 p.m. ET
Channel: CBS

Bet on New York vs. Tampa Bay with FanDuel Sportsbook.

Commanders vs. Cowboys

On Sunday at 1 p.m. ET, a pair of outstanding pass-catchers will be featured when Terry McLaurin and the Washington Commanders host CeeDee Lamb and the Dallas Cowboys.

Matchup: Dallas Cowboys at Washington Commanders
Projected Favorite: Commanders (86.08% win probability)
Spread: Washington (-10.5)
Total: 44.5 -- Over: (-115) | Under: (-105)
Time: 1 p.m. ET
Channel: FOX

Bet on Washington vs. Dallas with FanDuel Sportsbook.

Raiders vs. Broncos

Star pass-catcher Brock Bowers will lead the Las Vegas Raiders into their matchup versus the Denver Broncos at Allegiant Stadium on Sunday at 4:05 p.m. ET.

Matchup: Denver Broncos at Las Vegas Raiders
Projected Favorite: Broncos (74.33% win probability)
Spread: Denver (-5.5)
Total: 41.5 -- Over: (-105) | Under: (-115)
Time: 4:05 p.m. ET
Channel: CBS

Bet on Las Vegas vs. Denver with FanDuel Sportsbook.

Seahawks vs. Cardinals

One of the top pass-catchers in football will be on display when Trey McBride and the Arizona Cardinals visit the Seattle Seahawks on Sunday, November 24, 2024.

Matchup: Arizona Cardinals at Seattle Seahawks
Projected Favorite: Cardinals (61.98% win probability)
Spread: Arizona (-1.5)
Total: 47.5 -- Over: (-110) | Under: (-110)
Time: 4:25 p.m. ET
Channel: FOX

Bet on Seattle vs. Arizona with FanDuel Sportsbook.

Packers vs. 49ers

When the Green Bay Packers (7-3) and the San Francisco 49ers (5-5) square off on Sunday, Nov. 24 at 4:25 p.m. ET, the Packers will be looking to follow up their recent victory over the Bears with another win, and the 49ers will be trying to bounce back from a loss to the Seahawks.