Michigan vs Duke College Basketball Prediction, Odds, Picks, Best Bets for Feb. 21

The Michigan Wolverines (25-1) will look to continue an 11-game winning streak when they visit the Duke Blue Devils (24-2) on February 21, 2026. The Blue Devils have won three games in a row.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Michigan vs. Duke Game Info and Odds

• Game day: Saturday, February 21, 2026
• Game time: 6:30 p.m. ET
• TV channel: ESPN
• Location: Washington D.C.
• Arena: Capital One Arena

Before making a wager on Saturday's Michigan-Duke spread (Michigan -2.5) or over/under (150.5 points), check out the betting trends and insights below.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Michigan vs. Duke: ATS Betting Stats and Trends

• Michigan has put together a 14-12-0 record against the spread this season.
• Duke has put together a 13-13-0 record against the spread this season.
• The Wolverines have covered the spread in a higher percentage of their home games than road games. They have covered eight times in 13 opportunities when playing at home, and they've covered three times in nine opportunities in away games.
• The Blue Devils' winning percentage against the spread at home is .385 (5-8-0). Away, it is .667 (6-3-0).

Michigan vs. Duke: Moneyline Betting Stats

• Michigan has come away with 23 wins in the 24 contests it has been listed as the moneyline favorite in this season.
• This season, the Wolverines have been victorious 21 times in 22 chances when named as a favorite of at least -166 or better on the moneyline.
• Duke is the moneyline underdog for the first time this season.
• The Blue Devils have not yet played a game with moneyline odds of +138 or longer.
• Michigan has an implied victory probability of 62.4% according to the moneyline set by oddsmakers for this matchup.

Michigan vs. Duke Head-to-Head Comparison

• Michigan averages 90.6 points per game (fourth in college basketball) while giving up 68.8 per contest (60th in college basketball). It has a +568 scoring differential overall and outscores opponents by 21.8 points per game.
• Yaxel Lendeborg ranks 348th in the country with a team-high 14.4 points per game.
• Duke is outscoring opponents by 19.8 points per game, with a +515 scoring differential overall. It puts up 83.0 points per game (45th in college basketball) and allows 63.2 per contest (third in college basketball).
• Duke's leading scorer, Cameron Boozer, is fifth in college basketball, averaging 22.8 points per game.
• The Wolverines win the rebound battle by 10.9 boards on average. They record 38.2 rebounds per game, which ranks fifth in college basketball, while their opponents grab 27.3 per contest.
• Lendeborg's 7.5 rebounds per game lead the Wolverines and rank 105th in college basketball play.
• The Blue Devils are 24th in the nation at 36.8 rebounds per game. That's 10.3 more than the 26.5 their opponents average.
• Boozer averages 10.0 rebounds per game (13th in college basketball) to lead the Blue Devils.
• Michigan ranks 11th in college basketball by averaging 109.0 points per 100 possessions on offense, and defensively is fourth in college basketball, allowing 82.7 points per 100 possessions.
• The Blue Devils record 108.3 points per 100 possessions (17th in college basketball), while giving up 82.4 points per 100 possessions (third in college basketball).

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!