Michigan vs Duke College Basketball Prediction, Odds, Picks, Best Bets for Feb. 21

Two streaking teams square off when the Michigan Wolverines (25-1) visit the Duke Blue Devils (24-2) on February 21, 2026. The Wolverines will put their 11-game win streak on the line against the Blue Devils, who have won three straight.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Michigan vs. Duke Game Info and Odds

• Game day: Saturday, February 21, 2026
• Game time: 6:30 p.m. ET
• TV channel: ESPN
• Location: Washington D.C.
• Arena: Capital One Arena

Michigan vs. Duke Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Michigan win (54.7%)

Before placing a bet on Saturday's Michigan-Duke spread (Michigan -2.5) or total (150.5 points), see the betting insights and trends below.

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Michigan vs. Duke: ATS Betting Stats and Trends

• Michigan has won 14 games against the spread this season, while failing to cover 12 times.
• Duke is 13-13-0 ATS this year.
• The Wolverines have covered the spread in a higher percentage of their home games than road games. They have covered eight times in 13 opportunities at home, and they've covered three times in nine opportunities on the road.
• Against the spread, the Blue Devils have had better results away (6-3-0) than at home (5-8-0).

Michigan vs. Duke: Moneyline Betting Stats

• Michigan has been the moneyline favorite in 24 games this season and has come away with the win 23 times (95.8%) in those contests.
• This season, the Wolverines have been victorious 21 times in 22 chances when named as a favorite of at least -156 or better on the moneyline.
• Duke has not played as the moneyline underdog so far this season.
• The Blue Devils have yet to play a game with moneyline odds of +130 or longer.
• The moneyline set for this matchup implies Michigan has a 60.9% chance of walking away with the win.

Michigan vs. Duke Head-to-Head Comparison

• Michigan's +568 scoring differential (outscoring opponents by 21.8 points per game) is a result of scoring 90.6 points per game (fourth in college basketball) while giving up 68.8 per contest (60th in college basketball).
• Michigan's leading scorer, Yaxel Lendeborg, ranks 346th in college basketball putting up 14.4 points per game.
• Duke puts up 83 points per game (46th in college basketball) while allowing 63.2 per contest (third in college basketball). It has a +515 scoring differential and outscores opponents by 19.8 points per game.
• Cameron Boozer paces Duke, putting up 22.8 points per game (fifth in college basketball).
• The Wolverines are sixth in the country at 38.2 rebounds per game. That's 10.9 more than the 27.3 their opponents average.
• Lendeborg averages 7.5 rebounds per game (ranking 105th in college basketball) to lead the Wolverines.
• The Blue Devils win the rebound battle by 10.3 boards on average. They record 36.8 rebounds per game, 24th in college basketball, while their opponents grab 26.5.
• Boozer is 13th in the country with 10 rebounds per game, leading the Blue Devils.
• Michigan ranks 13th in college basketball with 109 points scored per 100 possessions, and fifth in college basketball defensively with 82.7 points conceded per 100 possessions.
• The Blue Devils rank 17th in college basketball averaging 108.3 points per 100 possessions on offense, and defensively are fourth, allowing 82.4 points per 100 possessions.

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