Michigan State vs Ohio State College Basketball Prediction, Odds, Picks, Best Bets for Feb. 22

Big Ten play on Sunday will see the the No. 15 Michigan State Spartans (21-5, 11-4 Big Ten) host the Ohio State Buckeyes (17-9, 9-6 Big Ten) at Jack Breslin Students Events Center, starting at 1 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Michigan State vs. Ohio State Game Info and Odds

• Game day: Sunday, February 22, 2026
• Game time: 1 p.m. ET
• TV channel: CBS
• Location: East Lansing, Michigan
• Arena: Jack Breslin Students Events Center

Michigan State vs. Ohio State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Michigan State win (78.8%)

Before placing a bet on Sunday's Michigan State-Ohio State spread (Michigan State -10.5) or over/under (146.5 points), check out the betting trends and insights below.

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Michigan State vs. Ohio State: ATS Betting Stats and Trends

• Michigan State has compiled a 14-12-0 record against the spread this season.
• Ohio State has put together a 12-14-0 record against the spread this year.
• Michigan State (5-8) covers a lower percentage of games when it is favored by 10.5 points or more this season (38.5%) than Ohio State (1-0) does as a 10.5+-point underdog (100%).
• The Spartans have covered the spread in a higher percentage of their home games than road games. They have covered eight times in 15 opportunities at home, and they've covered three times in seven opportunities in road games.
• The Buckeyes have been better against the spread away (4-4-0) than at home (6-9-0) this season.
• Michigan State has nine wins against the spread in 15 conference games this season.
• Ohio State has beaten the spread seven times in 15 Big Ten games.

Michigan State vs. Ohio State: Moneyline Betting Stats

• Michigan State has been chosen as the moneyline favorite in 21 games this year and has walked away with the win 19 times (90.5%) in those games.
• The Spartans have not lost in 11 games this year when favored by -649 or better on the moneyline.
• Ohio State has won two of the nine games it was listed as the moneyline underdog this season (22.2%).
• The Buckeyes have played as a moneyline underdog of +460 or longer in only one game this season, which they lost.
• The moneyline set for this matchup implies Michigan State has a 86.6% chance of walking away with the win.

Michigan State vs. Ohio State Head-to-Head Comparison

• Michigan State is outscoring opponents by 12.5 points per game with a +326 scoring differential overall. It puts up 78.9 points per game (113th in college basketball) and gives up 66.4 per contest (20th in college basketball).
• Michigan State's leading scorer, Jeremy Fears Jr., is 282nd in college basketball averaging 15.1 points per game.
• Ohio State outscores opponents by 7.8 points per game (posting 81.2 points per game, 69th in college basketball, and giving up 73.4 per contest, 164th in college basketball) and has a +202 scoring differential.
• Bruce Thornton leads Ohio State, putting up 19.9 points per game (34th in college basketball).
• The Spartans win the rebound battle by 12.6 boards on average. They collect 38.2 rebounds per game, which ranks sixth in college basketball, while their opponents pull down 25.6 per contest.
• Jaxon Kohler averages 9.3 rebounds per game (ranking 26th in college basketball) to lead the Spartans.
• The 30.7 rebounds per game the Buckeyes accumulate rank 256th in college basketball, 1.6 more than the 29.1 their opponents grab.
• Devin Royal's 5.6 rebounds per game lead the Buckeyes and rank 380th in college basketball.
• Michigan State averages 103.7 points per 100 possessions on offense (58th in college basketball), and allows 87.2 points per 100 possessions (34th in college basketball).
• The Buckeyes' 105.3 points per 100 possessions on offense rank 37th in college basketball, and the 95.3 points they allow per 100 possessions rank 192nd in college basketball.

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