Lakers vs. Celtics Prediction, Odds, Picks, Best Bets for Feb. 22

Lakers vs. Celtics Game Info

• Date: Sunday, February 22, 2026
• Time: 6:30 p.m. ET
• Venue: Crypto.com Arena -- Los Angeles, California
• Coverage: NBC/Peacock

A pair of the NBA's best scorers match up when Jaylen Brown (fourth, 29.2 PPG) and the Boston Celtics (36-19) visit Luka Doncic (first, 33 PPG) and the Los Angeles Lakers (34-21) on Sunday, February 22, 2026 at 6:30 p.m. ET on NBC/Peacock. The Celtics are 1.5-point favorites. The matchup has an over/under of 228.5.

Lakers vs. Celtics Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Lakers vs. Celtics Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (55.5%)

Lakers vs. Celtics Betting Trends

• The Celtics are 31-23-1 against the spread this season.
• The Lakers have 29 wins against the spread in 55 games this year.
• Celtics games have gone over the total 21 times this season.
• Lakers games this season have eclipsed the over/under 31 times in 55 opportunities (56.4%).
• Against the spread, Boston has played worse at home, covering 13 times in 27 home games, and 18 times in 28 road games.
• The Celtics have gone over the total in 10 of 27 home games (37%). They've fared better in away games, topping the total in 11 of 28 matchups (39.3%).
• This season, Los Angeles is 13-12-1 at home against the spread (.500 winning percentage). On the road, it is 16-13-0 ATS (.552).
• In terms of the over/under, Lakers games have finished over more frequently at home (18 of 26, 69.2%) than on the road (13 of 29, 44.8%).

Celtics Leaders

• Brown is averaging 29.2 points, 7 boards and 4.8 assists. Defensively, he averages 1 steal and 0.4 blocked shots.
• Derrick White's numbers on the season are 17.1 points, 4.4 boards and 5.6 assists per contest, shooting 38.8% from the floor and 32.1% from beyond the arc, with an average of 2.8 made 3-pointers.
• Nikola Vucevic's numbers on the season are 16.5 points, 8.9 boards and 3.6 assists per game, shooting 50.3% from the field and 37.9% from downtown, with an average of 1.7 made 3-pointers.
• Payton Pritchard averages 17.4 points, 4.2 rebounds and 5.4 assists, shooting 46.5% from the field and 36.1% from downtown, with 2.6 made 3-pointers per game.
• Neemias Queta is averaging 9.7 points, 8.2 rebounds and 1.5 assists.

Lakers Leaders

• Doncic averages 33 points, 7.8 rebounds and 8.6 assists. He is also draining 47.3% of his shots from the field and 35.2% from 3-point range, with 3.7 triples per contest (first in NBA).
• LeBron James' numbers on the season are 21.7 points, 5.7 boards and 7.2 assists per contest. He is making 49.9% of his shots from the field and 30.6% from beyond the arc, with an average of 1.4 treys.
• Deandre Ayton's numbers on the season are 13.2 points, 8.4 rebounds and 0.9 assists per game. He is making 67.1% of his shots from the field (second in league).
• Austin Reaves averages 25.6 points, 5.1 rebounds and 5.9 assists. He is making 51.1% of his shots from the field and 37.4% from 3-point range, with 2.6 treys per game.
• Jake LaRavia averages 9.3 points, 4 rebounds and 1.9 assists. He is draining 46.7% of his shots from the field and 33% from 3-point range, with 1.1 triples per game.

For more NBA betting insights, check out FanDuel Research's NBA home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Watch FanDuel TV's NBA show "Run It Back" with Lou Williams, Michelle Beadle, DeMarcus "Boogie" Cousins and Chandler Parsons weekdays at 10am ET on FanDuel TV, the Run It Back YouTube page, or download the podcast here: fanduel.com/research/tv-and-podcast.