Iowa State vs Tennessee College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Sweet 16

A place in the Elite Eight of the NCAA Tournament will go to either the No. 2 Iowa State Cyclones (29-7) or the No. 6 Tennessee Volunteers (24-11) when the teams meet in the Sweet 16. This game tips off at 10:10 p.m. ET on Friday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Tennessee Game Info and Odds

• Game day: Friday, March 27, 2026
• Game time: 10:10 p.m. ET
• TV channel: TBS
• Location: Chicago, Illinois
• Arena: United Center

Iowa State vs. Tennessee Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (58.6%)

To help you make an informed wager on Iowa State-Tennessee matchup (in which Iowa State is a 3.5-point favorite and the over/under has been set at 139.5 points), below are some betting trends and insights for Friday's game.

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Iowa State vs. Tennessee: ATS Betting Stats and Trends

• Iowa State has put together a 22-14-0 ATS record so far this year.
• Tennessee has covered 17 times in 35 games with a spread this year.
• As a 3.5-point underdog or more in 2025-26, Tennessee is 3-1 against the spread compared to the 19-11 ATS record Iowa State racks up as a 3.5-point favorite.
• The Cyclones have done a better job covering the spread in home games (9-8-0) than they have in road tilts (5-5-0).
• The Volunteers have performed better against the spread at home (8-9-0) than on the road (4-6-0) this season.

Iowa State vs. Tennessee: Moneyline Betting Stats

• Iowa State has won in 24, or 82.8%, of the 29 contests it has been named as the moneyline favorite in this year.
• This season, the Cyclones have been victorious 22 times in 26 chances when named as a favorite of at least -184 or better on the moneyline.
• Tennessee has been the underdog on the moneyline six total times this season. Tennessee has finished 3-3 in those games.
• The Volunteers have played as a moneyline underdog of +152 or longer in only one game this season, which they lost.
• Bookmakers have implied with the moneyline set for this matchup that Iowa State has a 64.8% chance of pulling out a win.

Iowa State vs. Tennessee Head-to-Head Comparison

• With 80.3 points scored per game and 68.3 points conceded last year, Iowa State was 34th in college basketball on offense and 61st on defense.
• Iowa State collected 32.7 rebounds per game and gave up 28.3 boards last year, ranking 142nd and 31st, respectively, in college basketball.
• Iowa State was 77th in college basketball in assists (15 per game) last season.
• In terms of turnovers, Iowa State was 232nd in the country in committing them (11.6 per game) last season. It was 13th-best in forcing them (14.4 per game).
• Tennessee averaged 74 points per game last year (167th-ranked in college basketball), but it really shined defensively, surrendering just 63.1 points per game (10th-best).
• Tennessee pulled down 33.2 rebounds per game last year (105th-ranked in college basketball), and it ceded just 27.5 rebounds per contest (13th-best).
• Last season Tennessee ranked 61st in college basketball in assists, dishing out 15.4 per game.
• Tennessee averaged 9.6 turnovers per game (40th-ranked in college basketball) this year, while forcing 10.5 turnovers per contest (250th-ranked).

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