Iowa State vs BYU College Basketball Prediction, Odds, Picks, Best Bets for Feb. 21

Big 12 action features the No. 6 Iowa State Cyclones (23-3, 10-3 Big 12) on the road against the No. 23 BYU Cougars (19-7, 7-6 Big 12) on Saturday, February 21, 2026 at 10:30 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. BYU Game Info and Odds

• Game day: Saturday, February 21, 2026
• Game time: 10:30 p.m. ET
• TV channel: ESPN
• Location: Provo, Utah
• Arena: Marriott Center

Before you bet on Saturday's Iowa State-BYU spread (Iowa State -2.5) or total (154.5 points), check out the betting trends and insights below.

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Iowa State vs. BYU: ATS Betting Stats and Trends

• Iowa State has put together a 15-11-0 ATS record so far this year.
• BYU has put together an 11-15-0 record against the spread this year.
• As a 2.5-point favorite or more in 2025-26, Iowa State is 14-11 against the spread compared to the 2-2 ATS record BYU puts up as a 2.5-point underdog.
• The Cyclones have covered the spread in a lower percentage of their home games than away games. They have covered eight times in 15 games when playing at home, and they've covered four times in seven games on the road.
• The Cougars' winning percentage against the spread at home is .333 (4-8-0). On the road, it is .429 (3-4-0).
• Against the spread, in conference games, Iowa State is 8-5-0 this year.
• BYU's Big 12 record against the spread is 4-9-0.

Iowa State vs. BYU: Moneyline Betting Stats

• Iowa State has been the moneyline favorite in 21 games this season and has come away with the win 18 times (85.7%) in those contests.
• The Cyclones have a mark of 17-3 in contests where sportsbooks favor them by -160 or better on the moneyline.
• BYU has yet to win a game it played as the moneyline underdog this season, going 1-0.
• The Cougars have played in three games as a moneyline underdog with odds of +132 or longer without earning a win.
• The moneyline set for this matchup implies Iowa State has a 61.5% chance of coming away with a victory in the contest.

Iowa State vs. BYU Head-to-Head Comparison

• At 80.3 points scored per game and 68.3 points conceded last year, Iowa State was 34th in the nation offensively and 61st on defense.
• Iowa State collected 32.7 rebounds per game and gave up 28.3 boards last season, ranking 142nd and 31st, respectively, in the nation.
• At 15 assists per game last season, Iowa State was 77th in the nation.
• In terms of turnovers, Iowa State was 232nd in college basketball in committing them (11.6 per game) last season. It was 13th-best in forcing them (14.4 per game).
• BYU ceded 72.6 points per game last year (199th-ranked in college basketball), but it really shined offensively, averaging 81.4 points per contest (24th-best).
• BYU ranked 19th-best in college basketball by allowing just 27.8 rebounds per game. It ranked 84th in college basketball by pulling down 33.5 boards per contest.
• BYU was one of the best teams in college basketball in terms of assists, as it delivered 17.2 per game (10th-best in college basketball).
• BYU was 215th in college basketball with 11.4 turnovers per game last season. Meanwhile, it ranked 184th with 11.2 forced turnovers per contest.

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