Houston vs Arizona College Basketball Prediction, Odds, Picks, Best Bets for Feb. 21

The Houston Cougars (23-3, 11-2 Big 12) will attempt to continue an 11-game home win streak when they host the Arizona Wildcats (24-2, 11-2 Big 12) on February 21, 2026 at Fertitta Center.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Houston vs. Arizona Game Info and Odds

• Game day: Saturday, February 21, 2026
• Game time: 3 p.m. ET
• TV channel: ABC
• Location: Houston, Texas
• Arena: Fertitta Center

Before making a wager on Saturday's Houston-Arizona spread (Houston -5.5) or total (141.5 points), take a look at the betting insights and trends below.

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Houston vs. Arizona: ATS Betting Stats and Trends

• Houston has compiled a 14-12-0 ATS record so far this year.
• Arizona has won 15 games against the spread this year, while failing to cover 11 times.
• Arizona covers the spread when it is a 5.5-point underdog or more 100% of the time. That's more often than Houston covers as a favorite of 5.5 or more (57.1%).
• At home, the Cougars have a better record against the spread (8-5-0) compared to their ATS record in road games (4-3-0).
• The Wildcats have been better against the spread away (4-3-0) than at home (7-8-0) this year.
• Houston is 8-5-0 against the spread in conference action this season.
• Arizona has seven wins against the spread in 13 Big 12 games this season.

Houston vs. Arizona: Moneyline Betting Stats

• Houston has been victorious in 19, or 90.5%, of the 21 contests it has been chosen as moneyline favorites in this season.
• The Cougars have not lost in 15 games this year when favored by -310 or better on the moneyline.
• Arizona has been the moneyline underdog only two other times so far this season, and it won both games.
• The Wildcats have not yet played a game with moneyline odds of +245 or longer.
• Bookmakers have implied with the moneyline set for this matchup that Houston has a 75.6% chance of pulling out a win.

Houston vs. Arizona Head-to-Head Comparison

• Offensively, Houston was the 182nd-ranked team in college basketball (73.7 points per game) last season. On defense, it was best (58.7 points conceded per game).
• On the boards, Houston was 96th in college basketball in rebounds (33.3 per game) last year. It was 10th-best in rebounds conceded (26.9 per game).
• Houston was 292nd in college basketball in assists (12 per game) last year.
• In terms of turnovers, Houston was third-best in college basketball in committing them (8.4 per game) last year. It was 85th in forcing them (12.3 per game).
• Arizona had a top-25 offense last season, ranking 16th-best in college basketball with 82.5 points per game. Defensively, it ranked 219th with 73.3 points allowed per contest.
• Arizona ranked 14th-best in the nation by pulling down 36.4 boards per game. In terms of rebounds allowed, it ranked 38th in college basketball (28.6 allowed per contest).
• Arizona delivered 16.2 assists per game, which ranked them 32nd in the nation.
• With 11.2 turnovers per game, Arizona ranked 186th in the country. It forced 10.9 turnovers per contest, which ranked 215th in college basketball.

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