Guardians vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 14

Odds updated as of 4:13 a.m.

The Cleveland Guardians are among the MLB squads in action on Tuesday, up against the St. Louis Cardinals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Cardinals Game Info

• Cleveland Guardians (10-7) vs. St. Louis Cardinals (8-8)
• Date: Tuesday, April 14, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CleGuardians.TV

Guardians vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-120) | STL: (+102)
• Spread: CLE: -1.5 (+142) | STL: +1.5 (-176)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Guardians vs Cardinals Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 1-0, 2.45 ERA vs Michael McGreevy (Cardinals) - 1-1, 2.16 ERA

The probable starters are Joey Cantillo (1-0) for the Guardians and Michael McGreevy (1-1) for the Cardinals. Cantillo and his team have covered in each of the three games he's started with a spread this season. Cantillo has yet to start a game this season when his team was the moneyline favorite. The Cardinals have a 2-1-0 record against the spread in McGreevy's starts. The Cardinals were named the moneyline underdog for two McGreevy starts this season -- they split the games.

Guardians vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51%)

Guardians vs Cardinals Moneyline

• St. Louis is the underdog, +102 on the moneyline, while Cleveland is a -120 favorite despite being on the road.

Guardians vs Cardinals Spread

• The Guardians are at the Cardinals and are favored by 1.5 runs (+142 to cover) on the runline. St. Louis is -176 to cover.

Guardians vs Cardinals Over/Under

• The over/under for the Guardians versus Cardinals contest on April 14 has been set at 8.5, with -106 odds on the over and -114 odds on the under.

Bet on Cleveland Guardians vs. St. Louis Cardinals on FanDuel today!

Guardians vs Cardinals Betting Trends

• The Guardians have won in two of the three contests they have been named as odds-on favorites in this year.
• Cleveland has played as a favorite of -120 or more just one time this year and came away with a win in that game.
• The Guardians and their opponents have hit the over in eight of their 17 games with a total set by oddsmakers this season.
• The Guardians are 11-6-0 against the spread in their 17 games with a line set by sportsbooks this season.
• The Cardinals have won 50% of the games this season they were the underdog on the moneyline (7-7).
• St. Louis has a 5-4 record (winning 55.6% of its games) when it has played as a moneyline underdog of +102 or longer.
• The Cardinals have had an over/under set by bookmakers 16 times, and have combined with opponents to go over the total in nine of those games (9-6-1).
• The Cardinals have put together a 7-9-0 record ATS this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 15 hits, batting .300 this season with nine extra-base hits. He has an on-base percentage of .379 and a slugging percentage of .680.
• Among qualified batters in the majors, his batting average ranks 41st, his on-base percentage ranks 42nd, and he is fifth in slugging.
• DeLauter hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .333 with four doubles, four walks and three RBIs.
• Jose Ramirez is batting .200 with four doubles, two home runs and nine walks, while slugging .354 with an on-base percentage of .297.
• Among qualifying batters, he ranks 141st in batting average, 128th in on-base percentage and 110th in slugging percentage.
• Ramirez heads into this matchup looking to extend his three-game hit streak. During his last five outings he is hitting .350 with two doubles, a home run, four walks and two RBIs.
• Angel Martinez has 15 hits this season and a team-best OBP of .385.
• Steven Kwan leads Cleveland with a slugging percentage of .339, fueled by three extra-base hits.

Cardinals Player Leaders

• Jordan Walker has accumulated a team-best OBP (.394) and slugging percentage (.767), and paces the Cardinals in hits (20, while batting .333).
• Including all qualified hitters in the majors, he ranks 11th in batting average, 31st in on-base percentage and first in slugging percentage.
• Walker hopes to build on a nine-game hitting streak in this matchup. During his last 10 games he is batting .366 with seven home runs, three walks and 12 RBIs.
• Alec Burleson has three doubles, two home runs and 11 walks while hitting .271. He's slugging .424 with an on-base percentage of .380.
• Including all qualified hitters, his batting average places him 64th, his on-base percentage ranks 40th, and he is 72nd in slugging.
• JJ Wetherholt is hitting .213 with a double, a home run and 10 walks.
• Ivan Herrera is batting .193 with three doubles and 14 walks.

Guardians vs Cardinals Head to Head

• 4/13/2026: 9-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/29/2025: 7-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/28/2025: 9-6 STL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/27/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/22/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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