Grizzlies vs. Spurs Prediction, Odds, Picks, Best Bets for March 25

Grizzlies vs. Spurs Game Info

• Date: Wednesday, March 25, 2026
• Time: 8 p.m. ET
• Venue: FedExForum -- Memphis, Tennessee
• Coverage: FDSSE, FDSSW, and WMC-TV

The San Antonio Spurs (54-18) visit the Memphis Grizzlies (24-47) after winning four home road in a row. The Spurs are heavy favorites by 16.5 points in the contest, which begins at 8 p.m. ET on Wednesday, March 25, 2026. The matchup's point total is 232.5.

Grizzlies vs. Spurs Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Grizzlies vs. Spurs Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Spurs win (70.7%)

Grizzlies vs. Spurs Betting Trends

• The Spurs have gone 37-30-4 against the spread this season.
• The Grizzlies have played 71 games, with 32 wins against the spread.
• Games involving the Spurs have hit the over 32 times out of 71 chances this season.
• Grizzlies games this season have gone over the total in 34 of 71 opportunities (47.9%).
• San Antonio has a worse record against the spread when playing at home (16-15-3) than it does in road games (21-15-1).
• When it comes to point totals, the Spurs hit the over more often at home, as they've exceeded the total 16 times in 35 opportunities this season (45.7%). On the road, they have hit the over 16 times in 37 opportunities (43.2%).
• Memphis' winning percentage against the spread at home is .471 (16-18-0). On the road, it is .432 (16-19-2).
• In terms of the over/under, Grizzlies games have finished over more frequently at home (18 of 34, 52.9%) than on the road (16 of 37, 43.2%).

Spurs Leaders

• Victor Wembanyama's numbers on the season are 24.3 points, 11.2 boards and 3 assists per game, shooting 50.4% from the field and 35.1% from downtown, with an average of 1.9 made treys.
• Stephon Castle's numbers on the season are 16.5 points, 5.1 boards and 7.1 assists per game, shooting 46.4% from the field and 31.8% from downtown, with an average of 1.1 made treys.
• Keldon Johnson averages 13 points, 5.4 rebounds and 1.3 assists.
• Julian Champagnie's numbers on the season are 11.1 points, 5.7 rebounds and 1.5 assists per game, shooting 43.6% from the floor and 38.2% from downtown, with an average of 2.4 made treys.
• Devin Vassell averages 14.1 points, 3.8 boards and 2.5 assists, shooting 43.8% from the field and 38.3% from downtown, with 2.5 made treys per game.

Grizzlies Leaders

• Cam Spencer averages 11.2 points for the Grizzlies, plus 2.6 boards and 5.4 assists.
• The Grizzlies receive 13.4 points per game from Cedric Coward, plus 6.2 boards and 2.8 assists.
• GG Jackson's numbers on the season are 11.8 points, 4.2 rebounds and 1.4 assists per contest. He is sinking 49.9% of his shots from the floor and 32.3% from 3-point range, with an average of 1.1 treys.
• The Grizzlies are receiving 7.3 points, 2 rebounds and 3.9 assists per game from Walter Clayton Jr.
• The Grizzlies receive 7.4 points per game from Taylor Hendricks, plus 3.6 boards and 1 assists.

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