Giants vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 17

Odds updated as of 2:12 a.m.

The MLB slate on Friday includes the San Francisco Giants taking on the Washington Nationals.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Nationals Game Info

• San Francisco Giants (7-12) vs. Washington Nationals (9-10)
• Date: Friday, April 17, 2026
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and NBCS-BA

Giants vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-164) | WSH: (+138)
• Spread: SF: -1.5 (+104) | WSH: +1.5 (-125)
• Total: 8 -- Over: (-110) | Under: (-110)

Giants vs Nationals Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 1-2, 5.25 ERA vs Zack Littell (Nationals) - 0-1, 4.20 ERA

The probable pitchers are Logan Webb (1-2) for the Giants and Zack Littell (0-1) for the Nationals. When Webb starts, his team is 1-3-0 against the spread this season. Webb's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 1-2. Littell has started two games with set spreads, and the Nationals covered in both chances. The Nationals were named the moneyline underdog for two Littell starts this season -- they won both.

Giants vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (59%)

Giants vs Nationals Moneyline

• Looking at the moneyline for Nationals-Giants, Washington is the underdog at +138, and San Francisco is -164 playing on the road.

Giants vs Nationals Spread

• The Giants are favored by 1.5 runs on the road against the Nationals. The Giants are +104 to cover the spread, while the Nationals are -125.

Giants vs Nationals Over/Under

• The over/under for the Giants versus Nationals game on April 17 has been set at 8, with -110 odds on the over and -110 odds on the under.

Bet on San Francisco Giants vs. Washington Nationals on FanDuel today!

Giants vs Nationals Betting Trends

• The Giants have won in one of the five contests they have been named as odds-on favorites in this year.
• These are the best odds of a victory sportsbooks have given San Francisco this season, with a -164 moneyline set for this game.
• The Giants and their opponents have gone over in eight of their 19 games with a total set by sportsbooks this season.
• In 19 games with a line this season, the Giants have a mark of 6-13-0 against the spread.
• The Nationals have a 9-9 record in games they were the underdog on the moneyline (winning 50% of those games).
• In games it has played as a moneyline underdog with odds of +138 or longer, Washington has gone 7-8 (46.7%).
• The Nationals have played in 19 games with an over/under set, and have combined with their opponents to go over the total 13 times (13-6-0).
• The Nationals are 12-7-0 against the spread this season.

Giants Player Leaders

• Luis Arraez leads San Francisco with an OBP of .351, plus a team-best slugging percentage of .388. He's batting .313 on the season.
• Among all qualified batters in the majors, his batting average ranks 23rd, his on-base percentage ranks 63rd, and he is 92nd in slugging.
• Matt Chapman has four doubles, a triple, a home run and five walks. He's batting .270 and slugging .392 with an on-base percentage of .316.
• Among qualifying hitters, he is 61st in batting average, 114th in on-base percentage and 91st in slugging percentage.
• Chapman has picked up at least one hit in two games in a row. In his last five games he is hitting .150 with a double and an RBI.
• Willy Adames leads San Francisco in total hits (19) this season, and 12 of those have gone for extra bases.
• Jung Hoo Lee is batting .246 with a .301 OBP and eight RBI for San Francisco this season.
• Lee enters this matchup on a three-game hitting streak. In his last five games he is batting .421 with two doubles, a walk and an RBI.

Nationals Player Leaders

• C.J. Abrams has accumulated 23 hits with a .481 on-base percentage and a .710 slugging percentage, all club-bests for the Nationals. He's batting .371.
• Including all the qualifying hitters in the majors, he ranks second in batting average, second in on-base percentage and second in slugging percentage.
• Abrams brings a seven-game hitting streak into this game. During his last 10 games he is hitting .452 with three doubles, three home runs, five walks and seven RBIs.
• James Wood is hitting .256 with six doubles, five home runs and 14 walks. He's slugging .526 with an on-base percentage of .376.
• He ranks 80th in batting average, 39th in on-base percentage and 29th in slugging percentage in MLB.
• Daylen Lile has a .337 slugging percentage, which paces the Nationals.
• Luis Garcia is hitting .233 with three doubles, a triple, a home run and three walks.

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