Duke vs Syracuse College Basketball Prediction, Odds, Picks, Best Bets for Feb. 16

The Syracuse Orange (15-11, 6-7 ACC) will try to break a four-game road slide when they take on the Duke Blue Devils (23-2, 12-1 ACC) on February 16, 2026 at Cameron Indoor Stadium.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Syracuse Game Info and Odds

• Game day: Monday, February 16, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Durham, North Carolina
• Arena: Cameron Indoor Stadium

Duke vs. Syracuse Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (93.7%)

Check out the betting trends and insights below before making a bet on Monday's Duke-Syracuse spread (Duke -19.5) or total (142.5 points).

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Duke vs. Syracuse: ATS Betting Stats and Trends

• Duke is 12-13-0 ATS this season.
• Syracuse has won 14 games against the spread this season, while failing to cover 12 times.
• In home games, the Blue Devils sport a worse record against the spread (4-8-0) compared to their ATS record in road games (6-3-0).
• Against the spread, the Orange have had better results on the road (4-2-0) than at home (8-8-0).
• Duke has six wins against the spread in 13 conference games this season.
• Syracuse is 8-5-0 against the spread in ACC games this season.

Duke vs. Syracuse: Moneyline Betting Stats

• Duke has been the moneyline favorite in 19 games this season and has come away with the win 17 times (89.5%) in those contests.
• The Blue Devils have been listed as a favorite of -4545 or more on two occasions this season and won both games.
• Syracuse has won 27.3% of the games this season it was the moneyline underdog (3-8).
• The Orange have never played a game this season with moneyline odds of +1600 or longer.
• Oddsmakers have implied with the moneyline set for this matchup that Duke has a 97.8% chance of pulling out a win.

Duke vs. Syracuse Head-to-Head Comparison

• Duke is outscoring opponents by 19.1 points per game with a +478 scoring differential overall. It puts up 82.2 points per game (58th in college basketball) and gives up 63.1 per outing (third in college basketball).
• Cameron Boozer's 22.8 points per game lead Duke and are fifth in college basketball.
• Syracuse outscores opponents by 4.3 points per game (posting 76.5 points per game, 167th in college basketball, and conceding 72.2 per contest, 132nd in college basketball) and has a +113 scoring differential.
• JJ Starling leads Syracuse, putting up 12.1 points per game (684th in college basketball).
• The Blue Devils rank 21st in the nation at 36.8 rebounds per game. That's 10.1 more than the 26.7 their opponents average.
• Boozer paces the Blue Devils with 9.9 rebounds per game (14th in college basketball play).
• The Orange lose the rebound battle by an average of 1.4 boards. They are recording 31.8 rebounds per game (205th in college basketball) compared to their opponents' 33.2.
• William Kyle III tops the Orange with 7.7 rebounds per game (90th in college basketball).
• Duke records 107.2 points per 100 possessions (23rd in college basketball), while giving up 82.3 points per 100 possessions (fifth in college basketball).
• The Orange rank 192nd in college basketball with 97.2 points scored per 100 possessions, and 106th defensively with 91.6 points conceded per 100 possessions.

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