Cubs vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 5

Odds updated as of 1:12 a.m.

The Chicago Cubs will face the Cleveland Guardians in MLB action on Sunday.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Guardians Game Info

• Chicago Cubs (3-4) vs. Cleveland Guardians (5-3)
• Date: Sunday, April 5, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MARQ

Cubs vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-144) | CLE: (+122)
• Spread: CHC: -1.5 (+116) | CLE: +1.5 (-140)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Cubs vs Guardians Probable Starting Pitchers

Probable Pitchers: Edward Cabrera (Cubs) - 1-0, 0.00 ERA vs Slade Cecconi (Guardians) - 0-1, 12.46 ERA

The probable pitchers are Edward Cabrera (1-0) for the Cubs and Slade Cecconi (0-1) for the Guardians. Cabrera helped his team cover the spread in his only opportunity this season as a starter. Cabrera's team won his only start as a favorite this season. Cecconi has started only one game with a set spread, which the Guardians failed to cover. The Guardians were the moneyline underdog for one Cecconi start this season -- they lost.

Cubs vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (50.7%)

Cubs vs Guardians Moneyline

• Looking at the moneyline for Cubs-Guardians, Chicago is the favorite at -144, and Cleveland is +122 playing at home.

Cubs vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Cubs. The Guardians are -140 to cover the spread, and the Cubs are +116.

Cubs vs Guardians Over/Under

• The over/under for the Cubs versus Guardians game on April 5 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

Bet on Chicago Cubs vs. Cleveland Guardians on FanDuel today!

Cubs vs Guardians Betting Trends

• The Cubs have been favorites in seven games this season and have come away with the win three times (42.9%) in those contests.
• This season Chicago has come away with a win three times in five chances when named as a favorite of at least -144 on the moneyline.
• Contests with the Cubs have gone over the total set by sportsbooks in three of seven chances this season.
• The Cubs are 3-4-0 against the spread in their seven games that had a posted line this season.
• The Guardians have a 5-3 record in games they were the underdog on the moneyline (winning 62.5% of those games).
• Cleveland has a 4-2 record (winning 66.7% of its games) when it has played as a moneyline underdog of +122 or longer.
• In the eight games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total three times (3-5-0).
• The Guardians have collected a 5-3-0 record against the spread this season (covering 62.5% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago with an OBP of .400, plus a team-best slugging percentage of .458. He's batting .292 on the season.
• Among qualified hitters in the majors, he ranks 52nd in batting average, 36th in on-base percentage, and 62nd in slugging.
• Ian Happ has five hits, which is best among Chicago batters this season. He's batting .179 with four extra-base hits. He's also slugging .536 with an on-base percentage of .281.
• He is 154th in batting average, 139th in on-base percentage and 37th in slugging among qualified batters.
• Alex Bregman has six hits this season and has a slash line of .214/.313/.429.
• Bregman takes a two-game hitting streak into this matchup. In his last five games he is hitting .263 with two home runs, three walks and three RBIs.
• Michael Busch has no home runs, but one RBI and a batting average of .240 this season.

Guardians Player Leaders

• Chase DeLauter has put up an on-base percentage of .370, a slugging percentage of .923, and has nine hits, all club-bests for the Guardians (while batting .346).
• Including all qualifying players in MLB, he is 18th in batting average, 59th in on-base percentage and first in slugging percentage.
• Jose Ramirez is batting .188 with two doubles, a home run and two walks. He's slugging .344 with an on-base percentage of .235.
• He is 148th in batting average, 173rd in on-base percentage and 117th in slugging percentage in the majors.
• Steven Kwan is batting .233 with a double and four walks.
• Brayan Rocchio's .370 on-base percentage paces his team.

Cubs vs Guardians Head to Head

• 4/3/2026: 4-1 CLE (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/3/2025: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 7/2/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/1/2025: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/13/2024: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/12/2024: 9-8 CLE (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/30/2023: 10-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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