Cubs vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 24

Odds updated as of 10:12 p.m.

The Chicago Cubs will face the Houston Astros in MLB action on Sunday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Astros Game Info

• Chicago Cubs (29-23) vs. Houston Astros (22-31)
• Date: Sunday, May 24, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SCHN

Cubs vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-174) | HOU: (+146)
• Spread: CHC: -1.5 (+126) | HOU: +1.5 (-152)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Cubs vs Astros Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 4-4, 3.37 ERA vs Peter Lambert (Astros) - 2-4, 3.57 ERA

The Cubs will look to Shota Imanaga (4-4) against the Astros and Peter Lambert (2-4). When Imanaga starts, his team is 4-6-0 against the spread this season. When Imanaga starts a game and his team is the favorite on the moneyline, they have a record of 3-5. The Astros have a 2-4-0 record against the spread in Lambert's starts. The Astros have been the moneyline underdog in five of Lambert's starts this season, and they went 2-3 in those matchups.

Cubs vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (62.4%)

Cubs vs Astros Moneyline

• Chicago is the favorite, -174 on the moneyline, while Houston is a +146 underdog on the road.

Cubs vs Astros Spread

• The Cubs are favored by 1.5 runs at home versus the Astros. The Cubs are +126 to cover the spread, while the Astros are -152.

Cubs vs Astros Over/Under

• A total of 7.5 runs has been set for the Cubs-Astros game on May 24, with the over available at -110 and the under at -110.

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Cubs vs Astros Betting Trends

• The Cubs have come away with 20 wins in the 34 contests they have been listed as the favorites in this season.
• This season Chicago has been victorious four times in six chances when named as a favorite of at least -174 on the moneyline.
• The Cubs' games have gone over the total in 28 of their 51 opportunities.
• The Cubs are 21-30-0 against the spread in their 51 games with a line set by sportsbooks this season.
• The Astros have won 44.4% of the games this season they were the underdog on the moneyline (16-20).
• When playing as a moneyline underdog with odds of +146 or longer, Houston has a 2-5 record (winning only 28.6% of its games).
• The Astros have combined with opponents to hit the over on the total 28 times this season for a 28-23-2 record against the over/under.
• The Astros have put together a 22-31-0 record ATS this season (covering 41.5% of the time).

Cubs Player Leaders

• Nico Hoerner has an OPS of .724, fueled by an OBP of .345 and a team-best slugging percentage of .379 this season. He has a .256 batting average.
• Among all qualifying batters in baseball, he ranks 73rd in batting average, 61st in on-base percentage, and 109th in slugging.
• Dansby Swanson has four doubles, a triple, seven home runs and 24 walks. He's batting .189 and slugging .349 with an on-base percentage of .289.
• Among qualifiers, he ranks 162nd in batting average, 138th in on-base percentage and 137th in slugging percentage.
• Michael Busch has 41 hits this season and a team-best OBP of .354.
• Ian Happ is batting .214 with a .350 OBP and 20 RBI for Chicago this season.

Astros Player Leaders

• Yordan Alvarez has a team-high OBP (.415) and slugging percentage (.595), and paces the Astros in hits (57, while batting .300).
• Including all the qualifying hitters in MLB, his batting average is 13th, his on-base percentage is third, and he is fourth in slugging.
• Christian Walker has 10 doubles, 13 home runs and 19 walks while hitting .266. He's slugging .521 with an on-base percentage of .340.
• Including all qualifying hitters, he is 57th in batting average, 70th in on-base percentage and 18th in slugging percentage.
• Isaac Paredes has eight doubles, five home runs and 18 walks while hitting .246.
• Cam Smith is batting .208 with six doubles, four home runs and 19 walks.

Cubs vs Astros Head to Head

• 5/23/2026: 3-0 HOU (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/22/2026: 4-2 HOU (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/28/2025: 12-3 CHC (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/27/2025: 7-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/25/2024: 3-1 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/24/2024: 4-3 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/23/2024: 7-2 CHC (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/17/2023: 7-6 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/16/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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