Top 25 College Basketball Picks & Predictions Today - February 21

No. 3 Duke and No. 1 Michigan play at 6:30 p.m. ET, which is one of 17 games on Saturday that feature teams ranked in the Top 25 AP Poll. Check out all of the matchups below, along with our picks and predictions.

To pick up an edge prior to today's college basketball, see our odds breakdown below.

Ole Miss vs. Florida

• Matchup: No. 12 Florida Gators at Ole Miss Rebels
• Projected Winner: Florida (80.23% win probability)
• Spread: Florida (-13.5)
• Time: 12 p.m. ET
• Date: February 21
• TV Channel: ESPN

Bet on Ole Miss vs. Florida with FanDuel Sportsbook.

St. John's vs. Creighton

• Matchup: Creighton Bluejays at No. 17 St. John's Red Storm
• Projected Winner: St. John's (90.69% win probability)
• Spread: St. John's (-12.5)
• Time: 12 p.m. ET
• Date: February 21
• TV Channel: FOX

Bet on St. John's vs. Creighton with FanDuel Sportsbook.

Kansas vs. Cincinnati

• Matchup: Cincinnati Bearcats at No. 8 Kansas Jayhawks
• Projected Winner: Kansas (82.14% win probability)
• Spread: Kansas (-10.5)
• Time: 1 p.m. ET
• Date: February 21
• TV Channel: CBS

Bet on Kansas vs. Cincinnati with FanDuel Sportsbook.

Syracuse vs. North Carolina

• Matchup: No. 16 North Carolina Tar Heels at Syracuse Orange
• Projected Winner: North Carolina (65.70% win probability)
• Spread: North Carolina (-1.5)
• Time: 1 p.m. ET
• Date: February 21
• TV Channel: ABC

Bet on Syracuse vs. North Carolina with FanDuel Sportsbook.

Nebraska vs. Penn State

• Matchup: Penn State Nittany Lions at No. 9 Nebraska Cornhuskers
• Projected Winner: Nebraska (95.10% win probability)
• Spread: Nebraska (-18.5)
• Time: 2 p.m. ET
• Date: February 21
• TV Channel: BTN

Bet on Nebraska vs. Penn State with FanDuel Sportsbook.

Vanderbilt vs. Tennessee

• Matchup: Tennessee Volunteers at No. 19 Vanderbilt Commodores
• Projected Winner: Vanderbilt (70.19% win probability)
• Spread: Vanderbilt (-3.5)
• Time: 2 p.m. ET
• Date: February 21
• TV Channel: ESPN

Bet on Vanderbilt vs. Tennessee with FanDuel Sportsbook.

Virginia vs. Miami (FL)

• Matchup: Miami Hurricanes at No. 14 Virginia Cavaliers
• Projected Winner: Virginia (78.03% win probability)
• Spread: Virginia (-8.5)
• Time: 2 p.m. ET
• Date: February 21
• TV Channel: ESPN2

Bet on Virginia vs. Miami (FL) with FanDuel Sportsbook.

Louisville vs. Georgia Tech

• Matchup: Georgia Tech Yellow Jackets at No. 21 Louisville Cardinals
• Projected Winner: Louisville (98.26% win probability)
• Spread: Louisville (-22.5)
• Time: 2:15 p.m. ET
• Date: February 21
• TV Channel: The CW Network

Bet on Louisville vs. Georgia Tech with FanDuel Sportsbook.

Texas Tech vs. Kansas State

• Matchup: Kansas State Wildcats at No. 13 Texas Tech Red Raiders
• Projected Winner: Texas Tech (91.27% win probability)
• Spread: Texas Tech (-14.5)
• Time: 2:30 p.m. ET
• Date: February 21
• TV Channel: FOX

Bet on Texas Tech vs. Kansas State with FanDuel Sportsbook.

Houston vs. Arizona

• Matchup: No. 4 Arizona Wildcats at No. 2 Houston Cougars
• Projected Winner: Houston (65.16% win probability)
• Spread: Houston (-4.5)
• Time: 3 p.m. ET
• Date: February 21
• TV Channel: ABC

Bet on Houston vs. Arizona with FanDuel Sportsbook.

Arkansas vs. Missouri

• Matchup: Missouri Tigers at No. 20 Arkansas Razorbacks
• Projected Winner: Arkansas (82.67% win probability)
• Spread: Arkansas (-10.5)
• Time: 4 p.m. ET
• Date: February 21
• TV Channel: ESPN

Bet on Arkansas vs. Missouri with FanDuel Sportsbook.

Villanova vs. UConn

• Matchup: No. 5 UConn Huskies at Villanova Wildcats
• Projected Winner: Villanova (55.01% win probability)
• Spread: UConn (-1.5)
• Time: 5:30 p.m. ET
• Date: February 21
• TV Channel: TNT

Bet on Villanova vs. UConn with FanDuel Sportsbook.

LSU vs. Alabama

• Matchup: No. 25 Alabama Crimson Tide at LSU Tigers
• Projected Winner: Alabama (61.05% win probability)
• Spread: Alabama (-7.5)
• Time: 6 p.m. ET
• Date: February 21
• TV Channel: SEC Network

Bet on LSU vs. Alabama with FanDuel Sportsbook.

Duke vs. Michigan

• Matchup: No. 1 Michigan Wolverines vs. No. 3 Duke Blue Devils
• Projected Winner: Michigan (54.71% win probability)
• Spread: Michigan (-2.5)
• Time: 6:30 p.m. ET
• Date: February 21
• TV Channel: ESPN

Bet on Duke vs. Michigan with FanDuel Sportsbook.

UCLA vs. Illinois

• Matchup: No. 10 Illinois Fighting Illini at UCLA Bruins
• Projected Winner: Illinois (57.54% win probability)
• Spread: Illinois (-6.5)
• Time: 8 p.m. ET
• Date: February 22
• TV Channel: FOX

Bet on UCLA vs. Illinois with FanDuel Sportsbook.

Gonzaga vs. Pacific

• Matchup: Pacific Tigers at No. 11 Gonzaga Bulldogs
• Projected Winner: Gonzaga (94.04% win probability)
• Spread: Gonzaga (-20.5)
• Time: 9 p.m. ET
• Date: February 22
• TV Channel: ESPN+

Bet on Gonzaga vs. Pacific with FanDuel Sportsbook.

BYU vs. Iowa State

• Matchup: No. 6 Iowa State Cyclones at No. 23 BYU Cougars
• Projected Winner: BYU (54.86% win probability)
• Spread: Iowa State (-3.5)
• Time: 10:30 p.m. ET
• Date: February 22
• TV Channel: ESPN

Bet on BYU vs. Iowa State with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

For more college basketball betting insights, check out FanDuel Research's college basketball home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!