Christian McCaffrey Fantasy Football Week 16: Stats and Projections vs. Colts

In Week 16 (Monday at 8:15 p.m. ET), RB Christian McCaffrey and the San Francisco 49ers will play the Indianapolis Colts, who have the fourth-ranked run defense in the league (95.1 yards conceded per game).

Daily fantasy players, is McCaffrey worth considering for his upcoming game versus the Colts? See below, because we can help you make the correct decision.

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Christian McCaffrey Week 16 Fantasy Football Projection

• Matchup: San Francisco 49ers at Indianapolis Colts
• Game Date: December 22, 2025
• Game Time: 8:15 p.m.
• Projected Fantasy Points: 17.7
• PPR Projected Fantasy Points: 20.3
• Projected Rushing Yards: 76.38
• Projected Rushing TDs: 0.59
• Projected Receiving Yards: 47.67
• Projected Receiving TDs: 0.32

Projections provided by numberFire

McCaffrey Fantasy Performance

• At the RB position, McCaffrey has been one of the best players in fantasy, as he ranks fourth in the NFL with 18.4 fantasy points per game (258.2 total points). Overall, he is 15th in fantasy points.
• During his last three games, McCaffrey has 48.3 total fantasy points (16.1 per game), carrying the ball 66 times for 215 yards and three touchdowns. In the receiving game, he has added 88 yards on 12 catches (12 targets).
• McCaffrey has 88.0 total fantasy points (17.6 per game) in his last five games, carrying the ball 91 times for 326 yards with five touchdowns. In the receiving game, he has added 194 yards on 25 catches (28 targets) with one TDs.
• The peak of McCaffrey's fantasy campaign was a Week 7 outburst versus the Atlanta Falcons, a game when he came through with 129 rushing yards and two TDs on 24 carries (for 32.1 total fantasy points). As a receiver, he caught seven balls (on eight targets) for 72 yards.
• From a fantasy perspective, Christian McCaffrey stumbled to his worst performance of the season in Week 8 against the Houston Texans, rushing eight times for 25 yards, with three receptions for 43 yards as a receiver (6.8 fantasy points).

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Colts Defensive Performance

• Four players have recorded over 300 yards passing in a game against Indianapolis this season.
• A total of 10 players have thrown for at least one TD against the Colts this year.
• Indianapolis has allowed two or more passing TDs to five opposing QBs this year.
• Three players have thrown for at least three TDs in a game versus the Colts this season.
• Indianapolis has allowed six players to pick up over 100 yards receiving in a game this year.
• The Colts have given up a touchdown reception by 18 players this year.
• No player has caught more than one touchdown pass against Indianapolis this season.
• The Colts have given up more than 100 yards rushing to just one player this year.
• Indianapolis has allowed at least one rushing TD to 10 players this year.
• The Colts have allowed at least two rushing TDs to three players this year.

Want more data and analysis on Christian McCaffrey? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.