Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 6:12 p.m.

The MLB slate on Friday includes the Milwaukee Brewers facing the Pittsburgh Pirates.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Pirates Game Info

• Milwaukee Brewers (86-55) vs. Pittsburgh Pirates (64-77)
• Date: Friday, September 5, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: Apple TV+

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-138) | PIT: (+118)
• Spread: MIL: -1.5 (+122) | PIT: +1.5 (-146)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Quinn Priester (Brewers) - 11-2, 3.28 ERA vs Johan Oviedo (Pirates) - 2-0, 3.60 ERA

This contest's pitching matchup is set, as the Brewers will send Quinn Priester (11-2) to the mound, while Johan Oviedo (2-0) will answer the bell for the Pirates. When Priester starts, his team is 12-8-0 against the spread this season. Priester's team has been victorious in 77.8% of the games he's started as the moneyline favorite with a record of 7-2. The Pirates covered in all of Oviedo's four starts with a set spread. The Pirates are 3-1 in Oviedo's four starts this season that they were the underdog on the moneyline.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (55.7%)

Brewers vs Pirates Moneyline

• Looking at the moneyline for Brewers-Pirates, Milwaukee is the favorite at -138, and Pittsburgh is +118 playing at home.

Brewers vs Pirates Spread

• The Pirates are hosting the Brewers, and are +1.5 on the runline. The Pirates are +122 to cover the spread, and the Brewers are -146.

Brewers vs Pirates Over/Under

• The Brewers-Pirates game on Sept. 5 has been given an over/under of 8.5 runs. The over is set at -108 and the under at -112.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have come away with 50 wins in the 77 contests they have been listed as the favorites in this season.
• This season Milwaukee has been victorious 29 times in 41 chances when named as a favorite of at least -138 on the moneyline.
• The Brewers and their opponents have gone over in 69 of their 138 games with a total set by sportsbooks this season.
• The Brewers are 78-60-0 against the spread in their 138 games with a line set by sportsbooks this season.
• The Pirates have compiled a 41-52 record in games they were the underdog on the moneyline (winning 44.1% of those games).
• In games it has played as a moneyline underdog with odds of +118 or longer, Pittsburgh has a record of 24-38 (38.7%).
• The Pirates have played in 133 games with a set over/under, and have combined with their opponents to go over the total 53 times (53-74-6).
• The Pirates have put together a 74-59-0 record against the spread this season.

Brewers Player Leaders

• William Contreras is hitting .261 with 26 doubles, 17 home runs and 77 walks. He has an on-base percentage of .357 and a slugging percentage of .411.
• Among all qualified hitters in baseball, he ranks 73rd in batting average, 28th in on-base percentage, and 92nd in slugging.
• Contreras hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .300 with a double, a home run, two walks and three RBIs.
• Brice Turang leads Milwaukee in slugging percentage (.449) thanks to 44 extra-base hits. He's batting .291 with an on-base percentage of .358.
• Among qualifying batters, he ranks 15th in batting average, 25th in on-base percentage and 62nd in slugging percentage.
• Christian Yelich is batting .268 with a .464 slugging percentage and 92 RBI this year.
• Jackson Chourio leads Milwaukee in total hits (129) this season while batting .279 with 53 extra-base hits.

Pirates Player Leaders

• Bryan Reynolds has accumulated 127 hits with a .411 slugging percentage, both team-best numbers for the Pirates. He's batting .246 and with an on-base percentage of .313.
• Including all qualifying hitters in the big leagues, he ranks 108th in batting average, 113th in on-base percentage and 92nd in slugging percentage.
• Oneil Cruz is hitting .202 with 17 doubles, two triples, 19 home runs and 59 walks. He's slugging .389 with an on-base percentage of .304.
• Including all qualifying hitters, he ranks 152nd in batting average, 126th in on-base percentage and 122nd in slugging percentage.
• Andrew McCutchen has an on-base percentage of .342, a team-high for the Pirates.
• Tommy Pham is batting .264 with 16 doubles, a triple, eight home runs and 39 walks.

Brewers vs Pirates Head to Head

• 8/13/2025: 12-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/12/2025: 14-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/11/2025: 7-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/25/2025: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/24/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/23/2025: 5-4 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/25/2025: 6-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/24/2025: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2025: 6-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/22/2025: 8-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

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