Bills vs Chiefs NFL Odds, Predictions, Spread, Kickoff Time & Best Bets for AFC Divisional Round - January 21

NFL action on Sunday includes the Buffalo Bills taking on the Kansas City Chiefs.

Get the latest NFL odds ahead of this matchup on FanDuel Sportsbook.

Bills vs Chiefs Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (66.8%)

Bills vs Chiefs Point Spread

The Bills are 2.5-point favorites against the Chiefs. The Bills are -115 to cover the spread, while the Chiefs are -105 to cover as a 2.5-point underdog.

Bills vs Chiefs Over/Under

The Bills-Chiefs matchup on January 21 has been given an over/under of 45.5 points. The over is -115 and the under is -105.

Bills vs Chiefs Moneyline

Kansas City is the underdog, +128 on the moneyline, while Buffalo is a -152 favorite at home.

Bills vs Chiefs Betting Trends

• Buffalo was 7-10-0 against the spread during the season. It holds an ATS record of 1-0-0 in the playoffs.
• Against the spread as 2.5-point favorites or more, the Bills are 7-8 (in the regular season and playoffs).
• In the regular season, six of the Bills' 17 games hit the over. They are one of one in terms of exceeding the over/under in the postseason.
• Against the spread, the Chiefs were 10-7-0 during the regular season and are 1-0-0 in the playoffs.
• Kansas City is unbeaten ATS (1-0) as a 2.5-point underdog or more in the regular season and playoffs.
• There were five Chiefs games (out of 17) that hit the over in the regular season, and zero (of one) in the playoffs.

Bills vs Chiefs Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-152) | KC: (+128)
• Spread: BUF: -2.5 (-115) | KC: +2.5 (-105)
• Total: 45.5 -- Over: (-115) | Under: (-105)

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