Astros vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 19

Odds updated as of 9:14 p.m.

The Houston Astros versus the St. Louis Cardinals is on the MLB schedule for Sunday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Cardinals Game Info

• Houston Astros (8-13) vs. St. Louis Cardinals (11-8)
• Date: Sunday, April 19, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Cardinals.TV

Astros vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-142) | STL: (+120)
• Spread: HOU: -1.5 (+146) | STL: +1.5 (-176)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Astros vs Cardinals Probable Starting Pitchers

Probable Pitchers: Mike Burrows (Astros) - 1-3, 6.55 ERA vs Matthew Liberatore (Cardinals) - 0-1, 4.29 ERA

This contest's pitching matchup is set, as the Astros will send Mike Burrows (1-3) to the mound, while Matthew Liberatore (0-1) will get the nod for the Cardinals. Burrows and his team have a record of 1-3-0 against the spread when he starts. Burrows' team is 0-2 this season when he starts and they're favored on the moneyline. The Cardinals are 2-2-0 ATS in Liberatore's four starts that had a set spread. The Cardinals have been the underdog on the moneyline in four of Liberatore's starts this season, and they went 3-1 in those matchups.

Astros vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (57.9%)

Astros vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Astros, St. Louis is the underdog at +120, and Houston is -142 playing at home.

Astros vs Cardinals Spread

• The Astros are 1.5-run home favorites on the runline against the Cardinals. The Astros are +146 to cover, and the Cardinals are -176.

Astros vs Cardinals Over/Under

• The Astros-Cardinals contest on April 19 has been given an over/under of 8.5 runs. The over is set at -118 and the under at -104.

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Astros vs Cardinals Betting Trends

• The Astros have been victorious in five, or 38.5%, of the 13 contests they have been chosen as favorites in this season.
• This season Houston has been victorious four times in 10 chances when named as a favorite of at least -142 on the moneyline.
• The Astros' games have gone over the total in 14 of their 21 opportunities.
• In 21 games with a line this season, the Astros have a mark of 8-13-0 against the spread.
• The Cardinals have a 9-7 record in games they were the underdog on the moneyline (winning 56.2% of those games).
• When it has played as a moneyline underdog with odds of +120 or longer, St. Louis has a 2-3 record (winning 40% of its games).
• The Cardinals have had an over/under set by oddsmakers 19 times, and have combined with opponents to go over the total in 11 of those games (11-7-1).
• The Cardinals have covered 52.6% of their games this season, going 10-9-0 ATS.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.479), slugging percentage (.750) and total hits (24) this season. He has a .333 batting average.
• Among all qualifying batters in the majors, he is eighth in batting average, first in on-base percentage, and second in slugging.
• Alvarez will look for his fifth straight game with a hit in this matchup. In his last five games he is hitting .316 with two doubles, two home runs, three walks and five RBIs.
• Christian Walker is batting .278 with six doubles, four home runs and 10 walks, while slugging .528 with an on-base percentage of .369.
• Among all qualified, he ranks 51st in batting average, 41st in on-base percentage and 27th in slugging percentage.
• Jose Altuve has collected 22 base hits, an OBP of .404 and a slugging percentage of .493 this season.
• Altuve has recorded at least one base hit in two games in a row. In his last five games he is batting .273 with two doubles, a home run, a walk and an RBI.
• Carlos Correa has been key for Houston with 19 hits, an OBP of .346 plus a slugging percentage of .386.
• Correa heads into this game on a two-game hitting streak. In his last five games he is hitting .211 with two doubles and two walks.

Cardinals Player Leaders

• Jordan Walker has accumulated 23 hits with a .685 slugging percentage, both team-best numbers for the Cardinals. He's batting .315 and with an on-base percentage of .375.
• Including all the qualifying hitters in the majors, his batting average ranks 18th, his on-base percentage is 38th, and he is fourth in slugging.
• Jordan Walker brings a 12-game hitting streak into this matchup. During his last 10 outings he is batting .326 with a double, six home runs, three walks and eight RBIs.
• Alec Burleson is batting .292 with four doubles, two home runs and 12 walks. He's slugging .431 with an on-base percentage of .388.
• Including all qualified hitters, he ranks 35th in batting average, 28th in on-base percentage and 72nd in slugging percentage.
• JJ Wetherholt has a double, three home runs and 13 walks while hitting .232.
• Ivan Herrera's .398 OBP leads his team.

Astros vs Cardinals Head to Head

• 4/17/2026: 9-4 STL (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/16/2025: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/15/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/14/2025: 8-3 STL (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2024: 4-2 STL (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/4/2024: 8-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/3/2024: 7-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 6/29/2023: 14-0 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/28/2023: 10-7 HOU (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/27/2023: 4-2 STL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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