Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for April 5

Odds updated as of 7:19 a.m.

The Sunday slate in MLB includes a matchup between the Houston Astros and the Athletics.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Astros vs Athletics Game Info

• Houston Astros (6-3) vs. Athletics (2-6)
• Date: Sunday, April 5, 2026
• Time: 4:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-118) | OAK: (+100)
• Spread: HOU: -1.5 (+126) | OAK: +1.5 (-152)
• Total: 10 -- Over: (-105) | Under: (-115)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 1-0, 1.29 ERA vs Jacob Lopez (Athletics) - 0-1, 6.75 ERA

The Astros will look to Lance McCullers (1-0) versus the Athletics and Jacob Lopez (0-1). McCullers helped his team cover the spread in his only opportunity this season as a starter. McCullers has yet to start a game this season when his team was the moneyline favorite. Lopez has started just one game with a set spread, which the Athletics failed to cover. The Athletics were the moneyline underdog for one Lopez start this season -- they lost.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (52.9%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -118 favorite, while the Athletics are a +100 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +126 to cover, while the Athletics are -152 to cover.

Astros vs Athletics Over/Under

• The over/under for the Astros versus Athletics game on April 5 has been set at 10, with -105 odds on the over and -115 odds on the under.

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Astros vs Athletics Betting Trends

• The Astros have come away with three wins in the five contests they have been listed as the favorites in this season.
• This season, the Astros have come away with a win three times in five chances when named as a favorite of at least -118 or shorter on the moneyline.
• The Astros and their opponents have hit the over in seven of their nine games with a total this season.
• The Astros have posted a record of 6-3-0 against the spread this season.
• The Athletics have won one of the six games they were the moneyline underdog this season (16.7%).
• When they have played as a moneyline underdog with odds of +100 or longer, the Athletics have a record of 1-5 (16.7%).
• The Athletics have combined with their opponents to go over the total three times this season for a 3-5-0 record against the over/under.
• The Athletics have covered 50% of their games this season, going 4-4-0 against the spread.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.590), slugging percentage (.885) and total hits (11) this season. He has a .423 batting average.
• He ranks fourth in batting average, first in on-base percentage, and third in slugging among all qualified hitters in the majors.
• Christian Walker has hit one homers this season while driving in nine runs. He's batting .344 this season and slugging .625 with an on-base percentage of .417.
• He is 21st in batting average, 29th in on-base percentage and 17th in slugging in MLB.
• Jose Altuve has nine hits this season and has a slash line of .321/.500/.571.
• Carlos Correa has been key for Houston with eight hits, an OBP of .324 plus a slugging percentage of .364.

Athletics Player Leaders

• Shea Langeliers has put up an on-base percentage of .364, a slugging percentage of .800, and has nine hits, all club-highs for the Athletics (while batting .300).
• Including all the qualifying hitters in the majors, he ranks 43rd in batting average, 68th in on-base percentage and fifth in slugging percentage.
• Max Muncy is slugging .600 to pace his team. He has a batting average of .300 with an on-base percentage of .323.
• Including all qualifying hitters, he ranks 43rd in batting average, 104th in on-base percentage and 19th in slugging percentage.
• Jacob Wilson is batting .212 with three doubles.
• Lawrence Butler is hitting .200 with a home run and a walk.

Astros vs Athletics Head to Head

• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/25/2025: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/24/2025: 6-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/27/2025: 7-1 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/26/2025: 5-1 OAK (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/25/2025: 15-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/24/2025: 5-2 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/19/2025: 6-4 OAK (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)

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